Incidence of adverse events (>4% in any group)
| Adverse drug reaction | Number of adverse events (%) | |
| Placebo (n=442) | Acotiamide (n=450) | |
| Serum triglycerides increased | 91 (20.6) | 85 (18.9) |
| Serum prolactin increased | 30 (6.8) | 21 (4.7) |
| Serum bilirubin increased | 18 (4.1) | 19 (4.2) |
| Serum γ-glutamyltransferase increased | 28 (6.3) | 32 (7.1) |
| Serum alanine aminotransferase increased | 17 (3.8) | 18 (4.0) |
| White blood cell count increased | 21 (4.8) | 14 (3.1) |
| Diarrhoea | 18 (4.1) | 21 (4.7) |
| Nasopharyngitis | 41 (9.3) | 39 (8.7) |