Table 2

Correlations of eosinophil-derived protein concentrations from biopsy extracts and ESTs with histological measures of mucosal eosinophilia

A. BiopsiesPeak eosinophils* Mean eosinophils* EPX Staining Index*
r Value† p Valuer Value† p Valuer Value† p Value
MBP10.72559<0.00010.72003<0.00010.72052<0.0001
EDN0.78673<0.00010.79306<0.00010.75952<0.0001
ECP0.70621<0.00010.70804<0.00010.66968<0.0001
EPX0.61117<0.00010.61596<0.00010.60103<0.0001
CLC/Gal-100.66360<0.00010.66329<0.00010.65902<0.0001
B. ESTsEPX Staining Index*
r Value† p Value
MBP10.72170<0.0001
EDN0.47688<0.002
ECP0.20519NS
EPX0.54145<0.0002
CLC/Gal-100.72735<0.0001

  • ↵* n=41 subjects for peak and mean eosinophil numbers and EPX index.

  • ↵† Spearman's rank correlation coefficient (r) for values from n=41 subjects.

  • CLC/Gal-10, Charcot–Leyden crystal protein/galectin-10; ECP, eosinophil cationic protein; EDN, eosinophil-derived neurotoxin; EPX, eosinophil peroxidase; EST, oesophageal string test; MBP1, major basic protein-1.