Table 7

Surveillance protocol in LS

Site of cancerLower age limit (years)ExaminationInterval (years)
Uterus/ovaries35–40Offer gynaecological examination, transvaginal ultrasound, aspiration biopsy, discuss pros and cons1–2
Stomach30–35Upper gastrointestinal endoscopy only recommended in LS families from countries with high incidence of gastric cancer, preferably in research setting; Screening of all carriers >25 years for H pylori infection1–2
Urinary tract30–35Surveillance (by urine cytology and ultrasound) of MSH2 carriers only in research setting or if results are systematically collected by LS registry1
  • LS, Lynch syndrome.