Table 2

Cumulative risk (%) of non-colonic and non-endometrial cancers according to type of mismatch repair gene mutation by age 70 years

Tumour siteMutation carriersMLH1MSH2MSH6
AllMFAllMFAllMFAllMF
Gastric8 9 11–13 17 190.7/9.4/0.76.2/6.72.0/2.62.1/3/5/6/6.1/10.90.2/4.3/5.2/6/7/7.80/0/0/10.4
Small bowel9 11–13 15 190.6/2.5/4.24.1/6.1/122.7/3.9/4.10.4/4.4/4.5/7.2/81.1/1.3/4.5/5.9/80/0/0/3
Biliary tract8 11 130.6/1.4/21.9/30.02/0.40/0
Pancreas11 200.4/3.700.70
Urinary tract8 9 11–13 181.9/3.2/4/8.40.2/1.3/2.83.7/15.61.1/2.42.2/4.1/1227.8/18.211.9/8.40/0.72.60
Upper urinary tract12 18 196.09.1/9.45.4/6.012.1/4.82.4/0.4155.9/20.35.8/9.11.51.30
Bladder18 195.5/16.41.9/3.5110.80812.32.611.30
Ovaries8–13 196.1/8/12/13.53.4/3.9/5/5.5/6.3/20 7.5/8.3/10/10.4/11.6/240/1.0/10
Brain8 9 11 123.4/3.70/0.3/1.71.2/2.5/6.30
Prostate11 12 199.1/300 6/180/4
Breast12 16 19 5.4/14.418/17 1.5/1213