Covariates| | LR test* | Adjusted OR (95% CI) | p Value | Adjusted β coefficient† | Risk score‡ |
---|---|---|---|---|---|
Age group, years | <0.001 | ||||
40–49 | 1 | 0.002 | 0 | 0 | |
50–54 | 1.53 (1.16 to 2.02) | <0.001 | 0.43 | 1 | |
55–59 | 2.29 (1.75 to 3.00) | <0.001 | 0.83 | 2 | |
60–66 | 3.14 (2.40 to 4.12) | 1.15 | 3 | ||
Family history of CRC | <0.001 | ||||
None | 1 | <0.001 | 0 | 0 | |
One first-degree relative with CRC, aged ≥60 years | 1.40 (1.17 to 1.67) | <0.001 | 0.34 | 1 | |
One first-degree relative with CRC, aged <60 years | 1.66 (1.28 to 2.17) | 0.008 | 0.51 | 2 | |
Two first-degree relatives with CRC | 2.11 (1.22 to 3.66) | 0.75 | 2 | ||
Sex | <0.001 | ||||
Female | 1 | <0.001 | 0 | 0 | |
Male | 2.14 (1.71–2.67) | 0.76 | 2 | ||
Smoking history, pack-years§ | <0.001 | ||||
None | 1 | 0.654 | 0 | 0 | |
<10 | 1.05 (0.86 to 1.27) | 0.001 | 0 | 0 | |
10–19 | 1.34 (1.12 to 1.59) | <0.001 | 0.30 | 1 | |
≥20 | 1.60 (1.39 to 1.85) | 0.47 | 1 | ||
BMI (kg/m2) | 0.033 | ||||
<25 | 1 | 0.192 | 0 | 0 | |
25–29 | 1.14 (0.94 to 1.38) | 0.008 | 0 | 0 | |
≥30 | 1.34 (1.08 to 1.67) | 0.081 | 0.30 | 1 (0)¶ | |
Interaction with male sex** | |||||
25–29 | 0.78 (0.59 to 1.03) | 0.031 | 0 | ||
≥30 | 0.70 (0.51 to 0.97) | −0.35 |
*LR test, the likelihood ratio test for models with and without the specified covariate.
†Non-significant covariates were assigned β coefficient=0.
‡Model-adjusted coefficients were rounded up to the nearest one-half integer and then multiplied by two to avoid decimals.
§Regardless of current smoking status.
¶1 point for female sex and 0 point for male sex.
**Significant interaction was shown only between male sex and BMI.
BMI, Body Mass Index; CRC, colorectal cancer; LR, likelihood ratio test.