Table 1

Clinical and pathological characteristics of patients with OSCC with high- or low-risk lncRNA signature in the three datasets

Training set (n=60)Test set (n=59)Independent set (n=60)
CharacteristicsHigh-risk group (n=33)Low-risk group (n=27)p ValueHigh-risk group (n=25)Low-risk group (n=34)p ValueHigh-risk group (n=37)Low-risk group (n=23)p Value
Age, median (IQR)59.0 (11.0)55.0 (17.5)0.7976*62.0 (12.0)59.0 (9.5)0.3834*62.0 (13.0)58.0 (11.0)0.8231
Gender, male26 (78.8)23 (85.2)0.739121 (84.0)28 (82.4)1.000028 (75.7)20 (87.0)0.3404
Tobacco use, yes19 (57.6)20 (74.1)0.182518 (72.0)23 (67.6)0.719718 (48.6)16 (69.6)0.1119
Alcohol use, yes20 (60.6)16 (59.3)0.915616 (64.0)22 (64.7)0.955418 (48.6)14 (60.9)0.3562
Tumour location0.24600.54110.3780
 Upper7 (21.2)2 (7.4)1 (4.0)4 (11.8)5 (13.5)1 (4.3)
  Middle15 (45.5)17 (63.0)17 (68.0)20 (58.8)18 (48.6)10 (43.5)
  Lower11 (33.3)8 (29.6)7 (28.0)10 (29.4)14 (37.8)12 (52.2)
Tumour grade0.59770.31260.4270
 Well differntiated8 (24.2)6 (22.2)4 (16.0)5 (14.7)4 (10.8)5 (21.7)
 Moderately differentiated17 (51.5)17 (63.0)10 (40.0)20 (58.8)21 (56.8)13 (56.5)
 Poorly differentiated8 (24.2)4 (14.8)11 (44.4)9 (26.5)12 (32.4)5 (21.7)
T stage0.25240.16320.2271
 T11 (3.0)2 (7.4)1 (4.0)4 (11.8)1 (2.7)3 (13.0)
 T23 (9.1)2 (7.4)4 (16.0)11 (32.4)5 (13.5)2 (8.7)
 T317 (51.5)19 (70.4)15 (60.0)11 (32.4)31 (83.8)17 (73.9)
 T412 (36.4)4 (14.8)5 (20.0)8 (23.5)01 (6.3)
N stage0.13500.02900.7255
 N011 (33.3)16 (59.3)6 (24.0)21 (61.8)16 (43.2)13 (56.5)
 N118 (54.5)8 (29.6)9 (36.0)7 (20.6)14 (37.8)6 (26.1)
 N21 (3.0)2 (7.4)7 (28.0)3 (8.8)6 (16.2)3 (13.0)
 N33 (9.1)1 (3.7)3 (12.0)3 (8.8)1 (2.7)1 (4.3)
TNM stage0.11060.03780.5552
 I02 (7.4)04 (11.8)2 (5.4)2 (8.7)
 II10 (30.3)12 (44.4)8 (32.0)17 (50.0)17 (45.9)13 (56.5)
 III23 (69.7)13 (48.1)17 (68.0)13 (38.2)18 (48.6)8 (34.8)
Tumour clearanceN/AN/AN/A
 R033 (100)27 (100)25 (100)34 (100)37 (100)23 (100)
 R1/R2000000
Postoperative complication
 Pneumonia1 (3.0)1 (3.7)1.00006 (24.0)4 (11.8)0.29702 (5.4)1 (4.3)1.0000
 Anastomotic leak3 (9.1)1 (3.7)0.61993 (12.0)4 (11.8)1.00001 (2.7)01.0000
 Arrhythmia11 (33.3)5 (18.5)0.24819 (36.0)2 (5.9)0.005510 (27.0)6 (26.1)1.0000
Adjuvant therapy0.62090.25850.5196
 Yes20 (60.6)13 (48.1)16 (64.0)20 (58.8)23 (62.2)12 (52.2)
 No8 (24.2)9 (33.3)1 (4.0)6 (17.6)11 (29.7)10 (43.5)
 Unknown5 (15.2)5 (18.5)16 (27.1)8 (35.5)3 (8.1)1 (4.3)
Median survival (months)19.2>60<0.0001†21.5>600.0030†25.8>480.0187†
  • Data are shown as n (%). p Values are calculated by χ2 test or Fisher's exact test, unless otherwise stated.

  • *Student's t test.

  • †Log-rank test. N/A: p values are not calculated because all patients received R0 resection.

  • OSCC, oesophageal squamous cell carcinoma; TNM, tumour node metastasis.