Clinical, histological and viral data of 86 HBV-related HCC, classified by the TP53 R249S mutation or not
| R249S | Non-R249S | p Value | |
|---|---|---|---|
| Geographic origins | |||
| Africans | 57% (8/14) | 42% (30/72) | 0.02* |
| Asians | 36% (5/14) | 15% (11/72) | |
| Europeans | 7% (1/14) | 43% (31/72) | |
| HBV genotype | |||
| A | 36% (5/14) | 42% (30/72) | NS |
| B | 36% (5/14) | 5% (4/72) | 0.005* |
| C | 0% (0/14) | 17% (12/72) | NS |
| D | 14% (2/14) | 24% (17/72) | NS |
| E | 14% (2/14) | 7% (5/72) | NS |
| Undetermined | 0% (0/14) | 5% (4/72) | NS |
| Edmondson grade | |||
| Well differentiated (I–II) | 14% (2/13) | 43% (31/70) | 0.05** |
| Poorly differentiated (III–IV) | 79% (11/13) | 54% (39/70) | |
| Liver histology | |||
| Cirrhosis | 14% (2/14) | 50% (36/72) | 0.02* |
| Non-cirrhosis | 86% (12/14) | 50% (36/72) | |
| HBX sequence | |||
| Amino acid substitutions | 7% (1/14) | 33% (24/72) | 0.06* |
| Inactivating mutations | 93% (13/14) | 67% (48/72) | |
p Values obtained from Fisher's exact (*) and χ2 (**) tests based on the given clinical or viral variables are shown.
HCC, hepatocellular carcinoma.