An optimised logistic regression model (incorporating HLA Class I and II, IFNL3 and KIR) predicting viral clearance
| Explanatory variables | OR and confidence limits | p Value |
|---|---|---|
| A*02 | 2.32 (0.95 to 5.66) | 0.064 |
| A*03 | 0.36 (0.15 to 0.89) | 0.027 |
| A*11 | 2.36 (0.76 to 7.33) | 0.137 |
| B*07 | 0.49 (0.2 to 1.21) | 0.122 |
| B*27 | 0.12 (0.03 to 0.45) | <0.001 |
| C*02 | 32.38 (1.62 to 645) | 0.023 |
| DR*04:01 | 0.31 (0.12 to 0.85) | 0.022 |
| DR*01:01 | 0.2 (0.07 to 0.61) | 0.005 |
| DR*13:01 | 5.95 (0.97 to 36.67) | 0.054 |
| DQ*02:01 | 4.2 (2.04 to 8.66) | 0.008 |
| IFNL3 CC v CT/TT | 0.1 (0.04 to 0.23) | <0.001 |
| KIR2DS3 | 4.36 (1.62, 11.74) | 0.004 |
The explanatory variables are selected with stepwise selection minimising Akaike Information Criteria (AIC). OR, CIs and p values are presented. The dataset consists of patients from the Irish cohort (n=213). IFNL3 CC: protective genotype; IFNL3 CT/TT: deleterious genotype.