Cohorts | Cut-off values | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR– |
---|---|---|---|---|---|---|---|
Peg-IFN | ≥4.0 | 87.9 | 26.5 | 47.3 | 74.5 | 1.20 | 0.46 |
≥4.1 | 83.8 | 37.1 | 50.0 | 75.4 | 1.33 | 0.44 | |
≥4.2 | 72.7 | 46.2 | 50.3 | 69.3 | 1.35 | 0.59 | |
≥4.3 | 68.7 | 53.8 | 52.7 | 69.6 | 1.49 | 0.58 | |
≥4.4 | 60.6 | 66.7 | 57.7 | 69.3 | 1.82 | 0.59 | |
≥4.5 | 46.5 | 74.2 | 57.5 | 64.9 | 1.80 | 0.72 | |
NUC | ≥4.0 | 90.5 | 30.7 | 29.7 | 90.9 | 1.31 | 0.31 |
≥4.1 | 84.7 | 37.8 | 30.6 | 88.4 | 1.36 | 0.41 | |
≥4.2 | 73.0 | 49.4 | 31.8 | 85.0 | 1.44 | 0.55 | |
≥4.3 | 58.4 | 59.3 | 31.7 | 81.5 | 1.44 | 0.70 | |
≥4.4 | 48.9 | 68.8 | 33.7 | 80.6 | 1.57 | 0.74 | |
≥4.5 | 37.2 | 79.0 | 36.4 | 79.5 | 1.77 | 0.80 | |
Overall | ≥4.0 | 89.4 | 29.7 | 35.1 | 86.8 | 1.27 | 0.36 |
≥4.1 | 84.3 | 37.7 | 36.5 | 85.0 | 1.35 | 0.42 | |
≥4.2 | 72.9 | 48.6 | 37.6 | 80.8 | 1.42 | 0.56 | |
≥4.3 | 62.7 | 58.0 | 38.8 | 78.5 | 1.49 | 0.64 | |
≥4.4 | 53.8 | 68.3 | 41.9 | 77.7 | 1.70 | 0.68 | |
≥4.5 | 41.1 | 77.8 | 44.1 | 75.7 | 1.85 | 0.76 |
anti-HBc, hepatitis B core antibody; HBeAg, hepatitis B e antigen; LR−, negative likelihood ratio; LR+, positive likelihood ratio; NPV, negative predictive value; NUC, nucleos(t)ide analogue; Peg-IFN, peginterferon; PPV, positive predictive value.