Table 1

Univariate analysis of various clinical parameters and densities of intratumoral CD20+ B cells and CD3+ T cells as predictors of patient survival

VariablesNumber (%)Median (range)HR (95% CI)p Value
Grade (1+2/3+4)82/21 (80/20)NA0.4 (0.1 to 0.7)0.0055**
TNM stage (I+II/III+IV)64/45 (59/41)NA0.4 (0.2 to 0.7)0.0020**
Tumour size, cm (<median/≥median)NA5 (0.7–27)0.6 (0.3 to 1.0)0.0702ns
AFP (ng/mL) (<median/≥median)NA52 (1–>70 700)0.8 (0.5 to 1.4)0.4092ns
Age (<median/≥median)NA58 (20–84)0.5 (0.3 to 0.8)0.0106*
Viral status (non-infected/HepB+C)37/72 (34/66)NA1.1 (0.6 to 2.0)0.8163ns
Race (others/Chinese)26/83 (24/76)NA1.3 (0.6 to 2.6)0.4985ns
Gender (female/male)21/89 (19/81)NA0.7 (0.3 to 1.4)0.2903ns
CD20+ B cell density (<median/≥median)NA16 (0.3–199)3.1 (1.9 to 6.0)<0.0001****
CD3+ T cell density (<median/≥median)NA95 (5–840)2.9 (1.7 to 5.5)<0.0001****
  • *p<0.05 **p<0.01 ***p<0.001 ****p<0.0001. AFP, alpha-fetoprotein; TNM, tumour, node, metastases.