Table 2

Multivariate survival analysis by Cox regression model

Variables	HR (95% CI)	p Value
CD3⁺ T cell density	1.0086 (1.0010 to 1.0160)	0.0213*
CD20⁺ B cell density	1.0799 (1.0030 to 1.1630)	0.0424*
Grade	924 (54.42 to 15 700)	2.30e⁻⁰⁶***
as.factor (stage) II	25.3168 (0.1016 to 6308)	0.2511^ns
as.factor (stage) III	0.1002 (7.192e⁻⁰⁴ to 13.97)	0.3611^ns
as.factor (stage) IV	1411 (3.160 to 6.302e⁺⁰⁵)	0.0198*
Age	1.2322 (1.092 to 1.390)	6.80e⁻⁰⁴***
CD3:CD20	0.9999 (0.9999 to 1.000)	0.1795^ns
CD3:grade	0.9946 (0.9912 to 0.9981)	0.0022**
CD20:age	0.9987 (0.9975 to 0.9998)	0.0256*
Grade:age	0.9238 (0.8837 to 0.9658)	0.0005***
as.factor (stage) II:age	0.9810 (0.8997 to 1.0700)	0.6643^ns
as.factor (stage) III:age	1.0790 (0.9977 to 1.1670)	0.0571^ns
as.factor (stage) IV:age	0.9498 (0.8636 to 1.0450)	0.2892^ns

*p<0.05 **p<0.01 ***p<0.001 ****p<0.0001.