Risk of bias assessment
| Reference | Patient inclusion/exclusion criteria clearly defined | Patient treatment clearly characterised | Specimen characteristics | Adequate detection method of TP53 mutation | Study design | Study/statistical methods | Presentation (explanation of dropouts, number of events) | Reporting of basic demographic characteristics | Comparison of marker to standard prognostic variable | Univariate and/or time-to-event data presentation | Multivariable analysis adjusting for standard prognostic factors and adequate reporting hereof | Other potential sources of bias | Risk of bias |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fléjou et al39 | Low | Low | Low | High | Low | Low | Low | Low | Low | Low | High | Low | High |
| Duhaylongsod et al40 | Low | Low | Unclear | High | Low | High | Low | High | High | Low | High | Low | High |
| Sauter et al48 | Low | Low | Unclear | High | Low | Unclear | Low | Unclear | Unclear | Low | High | High | High |
| Ribeiro et al50 | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | High | Unclear | High |
| Soontrapornchai et al49 | Low | Low | Low | Low | Unclear | Low | Low | Low | Low | Low | High | Low | High |
| Wu et al41 | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low |
| Ireland et al42 | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low |
| Schneider et al43 | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low |
| Aloia et al51 | Low | Low | Low | High | Low | Low | Low | Low | Low | Low | Unclear | Low | High |
| Gibson et al52 | Low | Low | Low | Low | Low | Low | Low | Low | High | Low | High | High | High |
| Falkenbacket al44 | Low | Low | Low | High | Low | Low | Low | Low | Low | Low | Low | Low | High |
| Cavazzola et al47 | Low | Low | Low | High | Low | Low | Low | Low | Low | Low | Low | Low | High |
| Lehrbach et al46 | Low | Low | Low | High | Low | Low | Low | Low | Low | Low | High | Low | High |
| Madani et al45 | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | High | Unclear | High |
| Fareed et al53 | Low | Low | Unclear | High | Low | Low | Low | Low | Low | Low | High | Low | High |
| Kandioler et al54 | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low |