Systemic metabolic and inflammatory parameters in fasted mice over the time course of the treatment
| NC | NC-Co | HFD | HFD-Co | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameters | 1 month | 2 months | 3 months | 1 month | 2 months | 3 months | 1 month | 2 months | 3 months | 1 month | 2 months | 3 months |
| Insulinemia, pg/mL | 465±17 | 440±11 | 483±32 | 472±18 | 462±33 | 518±18 | 636±36§ | 736±57§ | 784±109§ | 671±41# | 732±62# | 836±105#* |
| Leptinemia, pg/mL | 741±505 | 683±376 | 760±385 | 940±263§ | 626±503 | 384±153 | 1626±589§ | 2023±451§ | 2347±254§ | 2209±63#* | 1177±418#* | 3474±421#* |
| IgG, µg/mL | 1411±82 | 1199±73 | 2836±857 | 1468±91 | 1360±388 | 2231±561 | 1690±522 | 3199±1230§ | 5933±947§ | 991±98#* | 2211±384#* | 2362±514* |
| IFN-γ, pg/mL | 36±25 | 230±106 | 255±420 | 13±8§ | 7±5§ | 14±7§ | 55±45 | 176±80 | 70±30 | 4±2* | 7±3* | 23±30* |
| IL-6, pg/mL | 4±1 | 8±2 | 9±4 | 19±8§ | 21±10§ | 8±5 | 2±1 | 4±1 | 2±1 | 16±6* | 18±5* | 22±4* |
| IP10, pg/mL | 73±17 | 108±17 | 138±25 | 100±33 | 87±13 | 95±10 | 81±18 | 93±12 | 100±19 | 96±15 | 110±18 | 126±7 |
| RANTES, pg/mL | 22±7 | 26±10 | 22±8 | 16±1 | 13±4 | 9±2 | 14±5 | 21±4 | 15±3 | 17±4 | 21±4 | 15±3 |
| MIG, pg/mL | 22±6 | 28±5 | 46±22 | 24±4 | 23±5 | 33±12 | 25±11 | 32±9 | 30±8 | 20±3 | 30±9 | 27±8 |
| Antibodies Anti-P. gingivalis (EI) | 1.45±0.24 | 1.54±0.24 | 1.49±0.14 | 3.89±2.44§ | 3.76±2.63§ | 3.58±1.82§ | 1.19±0.11 | 1.12±0.25 | 1.92±1.70 | 1.79±0.45# | 1.17±0.27# | 1.31±0.29# |
N=6 per group; data as mean±SEM.
One-way ANOVA followed by Tukey's test used for *p<0.05 when compared to HFD, §p<0.05 when compared to NC and #p<0.05 when compared to NC-Co.
HFD, high-fat diet (n=6); HFD-Co, high-fat diet colonised (n=6) in the table; IFN, interferon; IL, interleukin; NC, normal chow (n=6); NC-Co, normal chow colonised (n=6).