Diagnostic performance of faecal immunochemical test (FIT), marker Fusobacterium nucleatum (Fn) and the combined test for colorectal cancer (CRC) and advanced adenoma
| Marker/AUC | Discovery cohort | Validation cohort | All samples |
|---|---|---|---|
| CRC model | |||
| FIT | 0.86 (0.81–0.90) | 0.85 (0.76–0.94) | 0.85 (0.81–0.89) |
| Fn | 0.83 (0.78–0.89) | 0.89 (0.80–0.98) | 0.85 (0.80–0.90) |
| FIT+Fn | 0.95 (0.92–0.98) | 0.96 (0.92–0.99) | 0.95 (0.92–0.98) |
| (FIT+Fn) vs FIT | p<0.001 | p=0.0014 | p<0.001 |
| Advanced adenoma model | |||
| FIT | 0.57 (0.53–0.61) | 0.56 (0.51–0.61) | 0.56 (0.53–0.59) |
| Fn | 0.59 (0.51–0.67) | 0.58 (0.49–0.67) | 0.59 (0.53–0.65) |
| FIT+Fn | 0.65 (0.58–0.73) | 0.63 (0.55–0.72) | 0.65 (0.59–0.70) |
| (FIT+Fn) vs FIT | p=0.007 | p=0.031 | p<0.001 |
The AUC values of the discovery cohort, the validation cohort and the combined cohort were shown, fitting the logistic regression model from the discovery cohort. The one-sided Delong's test was used to test for incremental gain in AUC for the combined test over FIT.
AUC, area under the receiver-operating characteristic curve.