Patient characteristics (n=254)
| ASC | CH | LC | HCC | p Value | |
|---|---|---|---|---|---|
| n | 83 | 103 | 25 | 43 | |
| Age (years)* | 50 (26–83) | 49 (19–85) | 62 (35–74) | 63 (41–86) | <0.001 |
| Sex (M:F) | 36:47 | 63:40 | 18:7 | 31:12 | 0.002 |
| HBV genotype (A:B:C:D:ND) | 1:15:60:2:5 | 4:19:73:1:6 | 0:2:22:0:1 | 0:1:36:0:6 | NS |
| HBeAg+† | 2 (2.4%) | 31 (30.1%) | 8 (32.0%) | 9 (20.9%) | <0.001 |
| Alb (g/dL)* | 4.5 (3.2–5.2) | 4.4 (3.3–5.3) | 4.4 (2.1–4.6) | 4.2 (2.1–5.1) | <0.001 |
| AST (U/L)* | 21 (11–87) | 22 (13–238) | 24 (14–153) | 25 (14–99) | 0.006 |
| ALT (U/L)* | 18 (9–93) | 20 (8–375) | 18 (11–110) | 19 (8–57) | NS |
| ChE (U/L)* | 338 (189–848) | 314 (127–578) | 278 (74–382) | 265 (38–443) | <0.001 |
| T-cho (mg/dL)* | 194 (130–297) | 186 (94–315) | 171 (101–48) | 169 (85–257) | 0.013 |
| BUN (mg/dL)* | 12 (7–40) | 13 (1–39) | 14 (11–26) | 16 (9–31) | <0.001 |
| Cre (mg/dL)* | 0.65 (0.36–3.65) | 0.77 (0.37–6.2) | 0.78 (0.43–1.33) | 0.77 (0.45–1.99) | 0.002 |
| WBC (×102/μL)* | 50 (28–150) | 48 (21–93) | 44 (28–94) | 42 (15–85) | NS |
| Hb (g/dL)* | 13.8 (9.2–16.7) | 14.3 (9.9–18.0) | 14.0 (8.6–17.4) | 13.4 (8.7–16.4) | NS |
| Plt (×104/μL)* | 19.7 (9.5–49.7) | 17.8 (6.3–32.2) | 10.7 (4.7–20.3) | 11.7 (2.5–29.3) | <0.001 |
| AFP (ng/mL)* | 2.5 (0.7–80.1) | 2.5 (0.8–417.4) | 2.6 (1.5–23.0) | 3.0 (0.8–4834) | NS |
| HBsAg (IU/mL)* | 572 (1.1–64 510) | 1130 (1–50 460) | 823 (1–4326) | 199 (1–3212) | 0.001 |
| HBV DNA* (log copies/mL) | 3.2 (UD–9.0) | 2.1 (UD–9.1) | 2.1 (UD–7.3) | UD (UD–6.8) | <0.001 |
| IL-28B (TT:non-TT) | 67:16 | 76:27 | 13:12 | 34:9 | 0.031 |
| No treatment | 83 | 23 | 3 | 3 | <0.001 |
| Treatment with NUCs | 0 | 80 | 22 | 40 |
*Data are presented as the median (range).
†Data are presented as a positive number (%).
AFP, α-fetoprotein; Alb, albumin; ALT, alanine aminotransferase; ASC, asymptomatic carrier; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CH, chronic hepatitis; ChE, cholinesterase; Cre, creatine; Hb, haemoglobin; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; LC, liver cirrhosis; ND, not determined; NS, non-significant; NUC, nucleos(t)ide analogue; Plt, platelet count; T-cho, total cholesterol; TT, major homozygous genotype of IL-28B; UD, under detection threshold; WBC, white blood cell.