TableĀ 1
Exemplary HDAC targets in cancer
Oncogenic function
HDAC target gene
Cell cycle regulation
p21
Ku70
Inhibition of epithelial differentiation
GATA4
GATA6
DAB2
Muc2
Inhibition of apoptosis
p53
Bcl-xl
EMT and metastasis
CDH1
CXCR4
miR-203
EMT, epithelial-mesenchymal transition.