Table 1

Exemplary HDAC targets in cancer

Oncogenic functionHDAC target gene
Cell cycle regulationp21
Ku70
Inhibition of epithelial differentiationGATA4
GATA6
DAB2
Muc2
Inhibition of apoptosisp53
Bcl-xl
EMT and metastasisCDH1
CXCR4
miR-203

  • EMT, epithelial-mesenchymal transition.