Study | Cohort studied | Tissue sampled | Key findings |
---|---|---|---|
Kummen et al.1 Gut 2016 | 85 with PSC (55 with PSC–IBD and 30 PSC alone), 36 with UC and 263 healthy controls | Stool samples | Significantly distinct microbiota in PSC compared with UC and healthy controls. PSC and PSC–UC microbiota was similar. Veillonella genus was significantly increased compared with the other groups. |
Torres et al.5 Aliment Pharm Ther 2016 | 20 with PSC (19 with PSC–IBD and one with PSC only), 15 with IBD only and nine healthy controls | Pan-colonic and terminal ileal biopsies | No differences in the global microbiome profile; however, increased abundance of Blautia and Barnesiellaceae in PSC group along with major shifts in Clostridiales. |
Kevans et al.6 J Crohns Colitis 2016 | 31 with PSC–UC and 56 with UC | Left-sided colonic biopsies | No strong PSC-specific microbial associations in UC identified. |
Rossen et al.7 J Crohns Colitis 2015 | 12 with PSC–IBD, 11 with UC, and nine controls | Ileocecal biopsies | No cluster differentiation of microbiota between the groups. Reduced amounts of uncultured Clostridiales II in PSC biopsies in comparison with UC and healthy controls. |
Quraishi et al. | 11 with PSC–IBD, 10 with IBD and nine healthy controls | Pan-colonic biopsy | PSC–IBD microbiota significantly distinct from the other groups. Significant increase in Escherichia, Lachnospiraceae and Megasphera and decrease of Prevotella and Roseburia and a near-absence of Bacteroides in PSC–IBD. |
PSC–IBD, primary sclerosing cholangitis–IBD.