Results of published trials on endoscopic submucosal dissection for early Barrett's oesophagus neoplasia
| Author | Neuhaus17 | Kagemoto18 | Probst19 | Chevaux21 | Höbel20 |
|---|---|---|---|---|---|
| Study design | Prospective | Retrospective | Prospective | Retrospective | Retrospective |
| Patients | 30 | 23 | 87 | 75 | 22 |
| Mean procedural duration (min) | 75 | 93 | 140 | 117 | 114 |
| Mean diameter of the lesion (mm) | 20 | 19 | 21 | 20 | ND |
| Rates of resection | |||||
| En-bloc | 90% | 100% | 95% | 90% | 96% |
| R0 for EAC/HGIN | 39% | 85% | 74% | 64% | 82% |
| Curative for EAC/HGIN | 39% | 65% | 72% | 64% | 77% |
| Mean diameter of the specimen (mm) | 25 | ND | 39 | 53 | 44 |
| Adverse events | |||||
| Bleeding | 4% | 4% | 1% | 3% | 9% |
| Perforation | 0 | 0 | 0 | 4% | 5% |
| Stricture | 0 | 15% | 9% | 60% | 14% |
| CR of non-operated patients | |||||
| Neoplasia | 96% | 100% | 98% | 92% | 94% |
| IM | 54% | ND | 46% | 38% | ND |
| Ablation of residual IM | Yes | No | Yes | Yes | No |
| Follow-up | |||||
| Mean period (months) | 17 | 33 | 24 | 20 | 19 |
| Recurrent/metachronous neoplasia | 0 | 7% | 2% | 10% | 6% |
EAC, early adenocarcinoma; HGIN, high-grade intraepithelial neoplasia; IM, intestinal metaplasia.
ND, no data.