Table 3

Covariates associated with future risk of death or liver transplantation in the PSC derivation cohort

 Univariate analysisMultivariable analysis (adjusted for platelet count and serum albumin)*Multivariable analysis (adjusted for cirrhosis)*
Unadjusted HR (95% CI)p ValueAdjusted HR (95% CI)p ValueAdjusted HR (95% CI)p Value
Elevated serum AST (per IU/L increase)†1.01 (1.00 to 1.01)0.0061.01 (1.00 to 1.02)0.0031.02 (1.01 to 1.02)<0.001
Ascending cholangitis2.62 (1.20 to 5.72)0.0163.40 (1.46 to 7.90)0.0044.23 (1.72 to 10.42)0.002
Antibiotic exposure1.91 (1.24 to 2.92)0.003NSNSNSNS
Cirrhosis6.02 (1.83 to 20.00)0.003N/AN/A7.69 (2.04 to 27.03)0.002
Elevated serum bilirubin (per g/L increase)†1.02 (1.012 to 1.03)<0.001NSNSN/A
Thrombocytopenia (per 50×103 cells decrease)†1.22 (1.02 to 1.42)0.028NSNSN/A
Hypoalbuminaemia (per g/L decrease)†1.21 (1.12 to 1.30)<0.0011.18 (1.08 to 1.28)<0.001N/A
sVAP-1 (per 100 ng increase)†1.11 (1.11 to 1.22)0.002(Not included)(Not included)
sVAP-1: >529 ng/mL3.76 (1.68 to 8.47)0.0012.70 (1.03 to 714)0.0433.85 (1.57 to 9.34)0.003
  • *As platelet count and hypoalbuminaemia were used in defining cirrhosis as a covariate, their impact was determined on a singular as well as collective level in a stepwise multivariable Cox regression model.

  • †Values in parenthesis indicate that the degree of risk (HR in the adjacent columns) increases according to a unit change in the given variable.

  • AST, aspartate transaminase; NA, not applicable; NS, not significant; PSC, primary sclerosing cholangitis; VAP, vascular adhesion protein.