Table 3

Association of genotyped single-nucleotide polymorphisms (SNPs) at the TERT gene region with pancreatic cancer risk in five prospective cohorts

ParticipantsMAF
SNPLD†
r2
Major alleleMinor alleleCasesControlsCasesControlsPer minor allele
OR (95% CI)*
p Value
rs401681GA3628460.470.401.33 (1.12–1.59)0.002
rs27361000.01CA3638450.550.481.36 (1.13–1.63)0.001
rs4027100.59GA3608470.370.331.20 (1.00–1.44)0.047
rs28536760.007GA3638410.260.270.94 (0.76–1.15)0.540
  • *Conditional logistic regression model conditioned on matching factors (year of birth, prospective cohort, smoking status, fasting status and month/year of blood draw) and adjusted for history of diabetes mellitus (yes, no), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2) and physical activity (quartiles). OR reflects the OR per minor allele in an additive genetic model.

  • †LD of SNPs with rs401681 based on 1000G CEU data.

  • LD, linkage disequilibrium; MAF, minor allele frequency; TERT, telomerase reverse transcriptase.