Participants | MAF | ||||||||
---|---|---|---|---|---|---|---|---|---|
SNP | LD† r2 | Major allele | Minor allele | Cases | Controls | Cases | Controls | Per minor allele OR (95% CI)* | p Value |
rs401681 | – | G | A | 362 | 846 | 0.47 | 0.40 | 1.33 (1.12–1.59) | 0.002 |
rs2736100 | 0.01 | C | A | 363 | 845 | 0.55 | 0.48 | 1.36 (1.13–1.63) | 0.001 |
rs402710 | 0.59 | G | A | 360 | 847 | 0.37 | 0.33 | 1.20 (1.00–1.44) | 0.047 |
rs2853676 | 0.007 | G | A | 363 | 841 | 0.26 | 0.27 | 0.94 (0.76–1.15) | 0.540 |
*Conditional logistic regression model conditioned on matching factors (year of birth, prospective cohort, smoking status, fasting status and month/year of blood draw) and adjusted for history of diabetes mellitus (yes, no), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2) and physical activity (quartiles). OR reflects the OR per minor allele in an additive genetic model.
†LD of SNPs with rs401681 based on 1000G CEU data.
LD, linkage disequilibrium; MAF, minor allele frequency; TERT, telomerase reverse transcriptase.