Quintiles of leucocyte telomere length, z score | ||||||
---|---|---|---|---|---|---|
Q5 (longest) | Q4 | Q3 | Q2 | Q1 (shortest) | p Value, trend* | |
No. of cases | 64 | 84 | 72 | 71 | 95 | |
No. of controls | 179 | 180 | 179 | 178 | 180 | |
OR (95% CI)† | 1.0 | 1.35 (0.90–2.04) | 1.23 (0.79–1.93) | 1.27 (0.79–2.02) | 1.72 (1.07–2.78) | 0.048 |
OR (95% CI)‡ | 1.0 | 1.29 (0.85–1.96) | 1.20 (0.76–1.89) | 1.27 (0.80–2.04) | 1.67 (1.03–2.72) | 0.056 |
*p Value for trend calculated by the Wald test of a score variable containing median values of quintiles.
†Conditional logistic regression model conditioned on matching factors: year of birth, prospective cohort (HPFS, NHS, PHS, WHI-OS, WHS, which also matches on sex), smoking status (never, past, current), fasting status at blood collection (<8 hours, ≥8 hours) and month/year of blood collection.
‡Conditional logistic regression model conditioned on matching factors and adjusted for history of diabetes mellitus (yes, no), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2) and physical activity (quartiles).
HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; PHS, Physicians’ Health Study I; WHI-OS, Women's Health Initiative Observational Study; WHS, Women's Health Study.