Table 2

Association between prediagnostic leucocyte telomere length and future risk of pancreatic cancer

	Quintiles of leucocyte telomere length, z score
	Q5 (longest)	Q4	Q3	Q2	Q1 (shortest)	p Value, trend*
No. of cases	64	84	72	71	95
No. of controls	179	180	179	178	180
OR (95% CI)†	1.0	1.35 (0.90–2.04)	1.23 (0.79–1.93)	1.27 (0.79–2.02)	1.72 (1.07–2.78)	0.048
OR (95% CI)‡	1.0	1.29 (0.85–1.96)	1.20 (0.76–1.89)	1.27 (0.80–2.04)	1.67 (1.03–2.72)	0.056

*p Value for trend calculated by the Wald test of a score variable containing median values of quintiles.
†Conditional logistic regression model conditioned on matching factors: year of birth, prospective cohort (HPFS, NHS, PHS, WHI-OS, WHS, which also matches on sex), smoking status (never, past, current), fasting status at blood collection (<8 hours, ≥8 hours) and month/year of blood collection.
‡Conditional logistic regression model conditioned on matching factors and adjusted for history of diabetes mellitus (yes, no), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m²) and physical activity (quartiles).
HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; PHS, Physicians’ Health Study I; WHI-OS, Women's Health Initiative Observational Study; WHS, Women's Health Study.