Table 4

Association of single-nucleotide polymorphisms (SNPs) marking six previously identified, independent risk loci at the TERT gene region with pancreatic cancer in five prospective cohorts

ParticipantsMAF
Risk regionSNPMajor alleleMinor alleleCasesControlsCasesControlsPer minor allele OR (95% CI)*p Value
1rs7726159CA64411710.330.340.97 (0.81–1.16)0.741
2rs451360CA64411710.240.221.20 (1.00–1.43)0.044
3rs2853677AG64411710.400.410.92 (0.79–1.08)0.320
4rs2736098CT64411710.230.280.75 (0.63–0.90)0.002
5rs13172201TC64411710.260.261.02 (0.84–1.25)0.808
6rs10069690CT64411710.230.241.00 (0.83–1.21)0.996
  • *Unconditional logistic regression model adjusted for age (continuous) and prospective cohort (HPFS, NHS, PHS, WHI-OS, WHS). OR reflects the OR per minor allele in an additive genetic model.

  • HPFS, Health Professionals Follow-up Study; MAF, minor allele frequency; NHS, Nurses’ Health Study; PHS, Physicians’ Health Study I; TERT, telomerase reverse transcriptase; WHI-OS, Women's Health Initiative Observational Study; WHS, Women's Health Study.