Characteristics of ROC curves based on panel 1 and panel 2, for the discovery and validation cohorts
| Model | AUC | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|
| Panel 1: Control vs IBD (5 proteins) | |||||
| Discovery | 1.00 (0.99 to 1.0) | 1.0 (0.83 to 1.0) | 0.93 (0.78 to 0.99) | 0.91 | 1.0 |
| Validation | 0.99 (0.99 to 1.0) | 0.95 (0.75 to 1.0) | 0.97 (0.83 to 1.0) | 0.95 | 0.97 |
| Panel 2: CD vs UC (12 proteins) | |||||
| Discovery | 0.95 (0.86 to 1.0) | 1.0 (0.78 to 1.0) | 0.933 (0.68 to 1.0) | 0.94 | 1.0 |
| Validation | 0.86 (0.72 to 1.0) | 0.73 (0.45 to 0.92) | 0.87 (0.59 to 0.98) | 0.85 | 0.76 |
CD, Crohn's disease; NPV, negative predictive value; PPV, positive predictive value; ROC, receiving operating characteristics.