Serial pancreatic juice collections from a patient who developed pancreatic cancer during surveillance
| Case# | Time (months before PDAC diagnosis) | GNAS | KRAS | TP53 | SMAD4 | ||||
|---|---|---|---|---|---|---|---|---|---|
| dNGS# | SNV | dNGS# | SNV | dNGS# | SNV | dNGS# | SNV | ||
| Case#36_1 | 61 | 3 | p.R201C | 2 | p.G12D | 1 | p.R175H | 1 | p.Q256X |
| Case#36_2 | 16 | 0 | 3 | p.G12R | 4 | p.R175H | 1 | p.Q311X | |
| Case#36_3 | 4 | 2 | p.R201C | 21 | p.G12D | 1 | p.R175H | 26,4 | p.Q311X/p.Q256X |
| Case#36_ PDAC_tumour tissue | 0 | 1 | p.R201C | 75 | p.G12D | 0 | 90 | p.Q311X | |
dNGS#, digital NGS score (mutation concentration); NGS, next-generation sequencing; PDAC, pancreatic ductal adenocarcinoma; SNV, single nucleotide variant (ie, somatic mutation).