Relative abundance and prevalence of selected microbial taxa in patients with chronic gastritis and gastric carcinoma in the discovery cohort
| Taxa (phylum; class; order; family; genus) | Relative abundance (%)* | Prevalence (%)† | Univariate OR (95% CI) | Multivariate‡ OR (95% CI) | ||||
| Chronic gastritis | Gastric carcinoma | P§ | Chronic gastritis | Gastric carcinoma | P¶ | |||
| Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Phyllobacterium sp. | 0.2 | 5.4 | <0.0001 | 34.6 | 64.8 | 0.001 | 3.5 (1.7 to 7) | 3.7 (1.2 to 11) |
| Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Achromobacter sp. | 2.1 | 11.1 | <0.0001 | 24.7 | 87.0 | <0.0001 | 20.5 (7.4 to 59) | 56.3 (9.5 to 333) |
| Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria sp. | 3.9 | 0.4 | <0.0001 | 92.6 | 75.9 | <0.0001 | 0.25 (0.09 to 0.7) | 0.27 (0.1 to 1) |
| Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter sp. | 41.7 | 5.9 | <0.0001 | 100 | 85.2 | <0.0001 | 0.0 (0.0 to 0.4) | NA |
| Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Citrobacter sp. | 0.2 | 4.3 | <0.0001 | 30.9 | 81.5 | <0.0001 | 9.9 (4.3 to 23) | 6.5 (2.1 to 20) |
| Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus sp. | 0.025 | 4.7 | <0.0001 | 19.7 | 61.1 | <0.0001 | 6.3 (2.9 to 14) | 3.1 (1.0 to 10) |
| Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus sp. | 7.7 | 2.9 | <0.0001 | 97.5 | 92.6 | 0.217 | NA | NA |
| Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium sp. | 0.046 | 3.7 | <0.0001 | 8.6 | 35.2 | <0.0001 | 5.7 (2.2 to 15) | 7.8 (2.0 to 31) |
| Actinobacteria; Actinobacteria; Actinomycetales; Nocardiaceae; Rhodococcus sp. | 0.002 | 3.3 | <0.0001 | 9.9 | 31.5 | 0.003 | 4.2 (1.7 to 11) | 3.8 (1.0 to 15) |
| Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; Prevotella sp. | 5.0 | 2.0 | <0.0001 | 97.5 | 90.7 | 0.104 | NA | NA |
*Average relative abundance of specific taxa in subjects containing that taxa.
†Percentage of subjects carrying the specific taxa.
‡Multivariate logistic regression analysis with non-carriers as reference adjusted for age and gender.
§P values obtained through linear discriminatory analysis effect size (LEfSe).
¶P values obtained by Fisher’s exact test.
NA, not assessed.