Table 2

Incidence of recurrent peptic ulcer during 24 weeks of treatment in subgroups stratified by baseline characteristics

Characteristic	Recurrence rate, % (n/N)
Characteristic	Lansoprazole 15 mg	Vonoprazan 10 mg	Vonoprazan 20 mg
Helicobacter pylori status
Negative	3.3 (4/123)	0.9 (1/114)	2.6 (3/116)
Positive	2.3 (2/86)	0 (0/83)	0 (0/79)
CYP2C19 genotype
Extensive metaboliser	2.7 (5/184)	0.6 (1/162)	1.3 (2/155)
Poor metaboliser	3.6 (1/28)	0 (0/35)	2.4 (1/41)
Age
<65 years	1.4 (1/69)	1.9 (1/53)	0 (0/50)
≥65 to <75 years	2.2 (2/90)	0 (0/91)	2.0 (2/99)
≥75 years	5.6 (3/54)	0 (0/53)	2.1 (1/47)
Smoking status
Current or ex-smoker	1.8 (3/165)	0.6 (1/155)	1.9 (3/155)
Never smoker	6.3 (3/48)	0 (0/42)	0 (0/41)
Alcohol consumption status
Drinker	1.7 (2/119)	0.8 (1/126)	0.9 (1/117)
Never drink	4.3 (4/94)	0 (0/71)	2.5 (2/79)
Oral antithrombotic drug*
Yes	2.2 (2/91)	0 (0/83)	2.5 (2/79)
No	3.3 (4/122)	0.9 (1/114)	0.9 (1/117)

*Additional analysis.
CYP, cytochrome P450.