Cumulative incidence of cancers in groups of organs from 25 years of age up to the age indicated in the column Age, stratified on carriers of path_MMR variants in the different genes and 95% CIs in parentheses. Gynaecological cancer include endometrial and ovarian cancer. Upper gastrointestinal cancer include stomach, duodenum, bile duct, gall bladder or pancreas cancer. Genitorurinary tract cancer include urinary bladder, ureter or kidney
| ICD9 | Organ | Age | Cumulative incidence at age (% (95% CI)) | |||
| path_MLH1 | path_MSH2 | path_MSH6 | path_PMS2 | |||
| Any cancer | 40 | 16.8 (12.2 to 21.3) | 14.3 (8.0 to 20.3) | 0 | 0 | |
| 50 | 40.2 (34.7 to 45.7) | 37.2 (29.4 to 45.1) | 18.1 (8.0 to 28.3) | 0 | ||
| 60 | 58.7 (52.8 to 64.6) | 57.6 (49.3 to 65.9) | 39.0 (25.8 to 52.2) | 18.2 (0.0 to 41.0) | ||
| 70 | 71.7 (64.7 to 78.7) | 71.6 (61.9 to 81.2) | 53.6 (38.6 to 68.6) | 18.2 (0.0 to 41.0) | ||
| 75 | 75.8 (68.5 to 83.2) | 80.4 (69.8 to 90.9) | 60.9 (42.7 to 79.0) | 52.1 (0.1 to 100.0) | ||
| 153, 154 | Colorectal cancer | 40 | 12.7 (8.6 to 16.9) | 8.9 (4.0 to 13.7) | 0 | 0 |
| 50 | 25.0 (20.0 to 30.0) | 19.4 (13.0 to 25.8) | 1.8 (0.0 to 5.4) | 0 | ||
| 60 | 34.6 (28.9 to 40.3) | 27.1 (19.9 to 34.3) | 5.6 (0.0 to 11.9) | 0 | ||
| 70 | 40.1 (33.5 to 46.7) | 40.8 (31.6 to 50.1) | 15.0% (3.3 to 26.6) | 0 | ||
| 75 | 45.8 (37.8 to 53.9) | 43.0 (33.2 to 52.8) | 15.0 (3.3 to 26.6) | 0 | ||
| 182, 183 | Gynaecological cancer | 40 | 5.7 (2.1 to 9.3) | 5.2 (0.2 to 10.2) | 4.2 (0.0 to 12.3) | 0 |
| 50 | 24.6 (18.2 to 30.9) | 25.3 (16.1 to 34.5) | 19.2 (6.2 to 32.1) | 0 | ||
| 60 | 41.4 (33.6 to 49.2) | 49.2 (37.9 to 60.4) | 36.1 (19.2 to 53.1) | 26.4 (0.8 to 51.9) | ||
| 70 | 47.6 (38.9 to 56.4) | 62.1 (49.1 to 75.0) | 54.0 (34.6 to 73.4) | 26.4 (0.8 to 51.9) | ||
| 75 | 49.8 (40.5 to 59.0) | 65.7 (52.2 to 79.1) | 54.0 (34.6 to 73.4) | 26.4 (0.8 to 51.9) | ||
| 151, 152, 156, 157 | Upper gastrointestinal tract cancer | 40 | 1.0 (0.0 to 2.1) | 0 | 0 | 0 |
| 50 | 3.3 (1.4 to 5.1) | 1.5 (0.0 to 3.1) | 0 | 0 | ||
| 60 | 7.0 (4.3 to 9.7) | 4.1 (1.3 to 6.9) | 2.8 (0.0 to 6.7) | 0 | ||
| 70 | 17.1 (12.1 to 22.0) | 6.7 (2.7 to 10.6) | 2.8 (0.0 to 6.7) | 0 | ||
| 75 | 21.4 (15.6 to 27.1) | 10.2 (4.1 to 16.3) | 6.6 (0.0 to 14.8) | 0 | ||
| 188, 189 | Urinary tract | 40 | 0.3 (0.0 to 0.9) | 0 | 0 | 0 |
| 50 | 1.3 (0.2 to 2.5) | 3.4 (0.9 to 5.9) | 3.0 (0.0 to 7.0) | 0 | ||
| 60 | 3.0 (1.1 to 4.8) | 9.8 (5.6 to 14.0) | 5.7 (0.3 to 11.1) | 0 | ||
| 70 | 7.2 (3.8 to 10.6) | 21.3 (14.2 to 28.3) | 7.2 (1.1 to 13.3) | 0 | ||
| 75 | 8.0 (4.3 to 11.7) | 24.9 (16.6 to 33.2) | 11.0 (1.7 to 20.3) | 0 | ||