Regular ArticleContinuous HGF Supply from HGF-Expressing Fibroblasts Transplanted into Spleen Prevents CCl4-Induced Acute Liver Injury in Rats
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Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair
2009, Journal of Biological ChemistryCitation Excerpt :This was done by administering 1010 plaque-forming units of Ad-cyto-MetGFP or Ad-GFP intravenously to Plgo or Plg+ mice 2 days after CCl4, a time when the extensive centrilobular injury is fully established. We did not administer the virus before CCl4, because the administration of Hgf (and the presumed binding/activation of Met) prior to CCl4 has been shown to decrease the extent of liver injury (20, 21). Livers of Plgo mice treated with Ad-cyto-MetGFP expressed cyto-Met as far out as 12 days (or 14 days after CCl4; Fig. 8A).
Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice
2002, American Journal of Pathology
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