Biochemical and Biophysical Research Communications
Regular ArticleMice Lacking the Guanylyl Cyclase C Receptor Are Resistant to STa-Induced Intestinal Secretion☆
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2019, Journal of PediatricsCitation Excerpt :Binding of STa to GC-C leads to greatly increased cyclic guanosine monophosphate production with subsequent activation of the CFTR channel, resulting in secretory diarrhea.22,25 GUCY2C mutations leading to decreased GC-C activity may therefore blunt the secretory response to STa.14,15 Of note, GUCY2C−/− and GUCY2C +/− mice had increased survival after exposure to STa compared with GUCY2C +/+ mice.15,25,27 However, the fact that a significant number of Israeli−Bedouin individuals homozygous for pathogenic, loss-of-function mutations in GUCY2C eventually suffered from severe diarrhea highlights the need for further investigation into phenotypes and natural history of GUCY2C mutations.
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2018, Physiology of the Gastrointestinal Tract, Sixth EditionAntibody–drug conjugate directed against the guanylyl cyclase antigen for the treatment of gastrointestinal malignancies
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2016, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :It is also expressed on approximately 95% of metastatic colorectal cancer tumors, and subsets of gastric and pancreatic cancers. In tumor tissue, epithelial tight junctions are altered, and therefore it is expected that systemically delivered GCC-targeting agents would not affect GCC receptors in normal intestinal tissue but would have access to those in tumor tissue [8–10]. The ADC stability in vivo is crucial for targeted anti-tumor therapy.
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M. J. BlaserP. D. SmithJ. I. RavdinH. B. GreenbergR. L. Guerrant, Eds.
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