Biochemical and Biophysical Research Communications
Regular ArticleMacrophage Activation Includes High Intracellular Myeloperoxidase Activity
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Cited by (67)
Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target
2022, Pharmacology and TherapeuticsCitation Excerpt :During monocyte-to-macrophage differentiation, the expression of MPO is generally terminated (reviewed in Van Der Veen et al., 2009). However, MPO can be found in macrophage subpopulations (e.g. resident tissue macrophages such as Kupffer cells) (Brown, Brunt, & Heinecke, 2001), peritoneal macrophages (Rodrigues, Rodriguez, Russo, & Campa, 2002) and microglia (Nagra et al., 1997), as well as in tissue infiltrating macrophages in inflammatory diseases such as atherosclerosis (Malle et al., 2000) and multiple sclerosis (Nagra et al., 1997). MPO positive macrophages mainly acquired MPO protein by phagocytosis of apoptotic neutrophils or by uptake of extracellular MPO through the mannose receptor (Shepherd & Hoidal, 1990).
The acid response network of Staphylococcus aureus
2020, Current Opinion in MicrobiologyCitation Excerpt :On the one hand, bacteria encounter complex environments where both stressors coexist. Upon macrophage phagocytosis, vacuolar ATPase functions to decrease phagosomal pH to create an acidic environment, while intracellular myeloperoxidase produces reactive oxygen intermediates including hypochlorous acid (HOCl) from chloride ions and hydrogen peroxide [45,46]. On the other hand, acid stress is able to induce endogenous ROS generation.
Myeloperoxidase – A bridge linking inflammation and oxidative stress with cardiovascular disease
2019, Clinica Chimica ActaCitation Excerpt :It has been suggested that small amounts of MPO escape from the neutrophils (as proMPO monomers) and are released into the extracellular space [38]. Although MPO is predominantly found in neutrophils and monocytes, other cells including CD4+ and CD8+ lymphocytes [39], resident tissue macrophages such as Kupffer cells [40], peritoneal macrophages [41], and microglia [42], infiltrating macrophages in inflammatory diseases including atherosclerotic lesions [43] and vasculitis [44] show MPO activity. MPO activity has been detected in prostate tissue [45], neurons [46] and astrocytes [32].
Intestinal toxicity of oral warfarin intake in rats
2016, Food and Chemical ToxicologyCitation Excerpt :Increases of myeloperoxidase activity in tissue homogenates reflect neutrophil activity, as this enzyme is the major aspect of effector mechanisms of these leukocytes (Nathan, 2006). However, contribution of macrophages to the MPO activity could not be excluded as these cells produce this enzyme as well (Rodrigues et al., 2002). Increases in MPO represent, most probably, means of protection of intestinal tissue from intestinal bacteria which might reach injured tissue.
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