Clinical Immunology and Immunopathology
Regular ArticlePeripheral T Cell Response to A-Gliadin in Celiac Disease: Differential Processing and Presentation Capacities of Epstein-Barr-Transformed B Cells and Fibroblasts
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Vaccine against autoimmune disease: Antigen-specific immunotherapy
2013, Current Opinion in ImmunologyCitation Excerpt :Rational selection of epitopes for inclusion in ASIT or ESIT to maximize the responding T cell population requires analysis of the weight and quality of experimental evidence supporting epitopes as truly being disease relevant. The difficulty to identify the correct epitopes by establishing T cell lines from peripheral blood is illustrated by the observation that gluten-reactive intestinal T cell lines from HLA-DQ2.5+ celiac disease donors are almost exclusively HLA-DQ2.5-restricted and recognize gluten peptides deamidated by transglutaminase-2 [56,63], whereas peripheral blood T cell lines raised against native gluten are not consistently HLA-DQ2.5-restricted and do not show preference for deamidated gluten [56,64,65]. Table 1 summarizes the reliability of various approaches developed to test the toxicity gluten-derived peptides and ultimately define immunodominant T cell epitopes responsible for celiac disease.
The pathogenesis of celiac disease
1998, GastroenterologyHydrophobic interactions between gliadin and proteins and celiac disease
1996, Life SciencesBinding of peptides from the N-terminal region of α-gliadin to the celiac disease-associated HLA-DQ2 molecule assessed in biochemical and T cell assays
1996, Clinical Immunology and Immunopathology