Clinical Immunology and Immunopathology
Regular ArticleMolecular Mimicry as a Possible Cause of Autoimmune Reactions in Celiac Disease? Antibodies to Gliadin Cross-React with Epitopes on Enterocytes
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A phytochemical-rich diet may explain the absence of age-related decline in visual acuity of Amazonian hunter-gatherers in Ecuador
2015, Nutrition ResearchCitation Excerpt :With the exception of organisms that have evolved particular defenses to neutralize them, many dietary phytochemicals are poisonous [39–42]. Human defense receptors that detoxify phytochemicals in food can be overwhelmed by excessive intake [94–96], exemplified in conditions such as celiac disease [97,98]. Conversely, extensive variety and seasonally based dietary characteristics of wild forager diets, a norm through 99% of human evolutionary dietary history, avoided the concentrated toxic effect of the long-term narrower phytochemical spectrum that is the hallmark of the modern food system.
Identifying and reducing potentially wrong immunoassay results even when plausible and "not-unreasonable"
2014, Advances in Clinical ChemistryCitation Excerpt :They probably arise from commonplace activities such as keeping pets, ingesting animal antigens, vaccination, infection, and blood transfusion [34,79]. Interference may also be present in patients with autoimmune disease [80]. However, most assays’ format currently in use include reagents which are able to neutralize and block low concentrations (μg to mg/l) of some of these interfering antibodies, so that there is no or only minimal impact on analytical accuracy.
Molecular mimicry may contribute to pathogenesis of ulcerative colitis
2005, FEBS LettersEpitopes of calreticulin recognised by IgA autoantibodies from patients with hepatic and coeliac disease
2003, Journal of AutoimmunityOccurrence of IgA and IgG autoantibodies to calreticulin in coeliac disease and various autoimmune diseases
2000, Journal of AutoimmunityAnti-gliadin antibodies in patients with celiac disease cross-react with enterocytes and human calreticulin
1997, Clinical Immunology and Immunopathology