Clinical Immunology and Immunopathology
Regular ArticleCD8 T-Cells Are Not Essential for the Induction of “Low-Dose” Oral Tolerance
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Cited by (31)
Oral tolerance: an updated review
2022, Immunology LettersCitation Excerpt :C) Dendritic cells. As mentioned above and simplified in Fig. 1, intestinal DCs are responsible for presenting the antigen sampled in the gut to cognate naïve CD8+ and CD4+ T cells in the MLN, though the role of CD4+ T cells appears to be more important for oral tolerance induction than CD8+ T cells [35–40]. Several subtypes of gut DCs have been described and they are located in small and large intestine lamina propria as well as in PP and in MLN.
Mechanisms of Oral Tolerance to Soluble Protein Antigens
2015, Mucosal Immunology: Fourth EditionInduction of mucosal tolerance in SLE: A sniff or a sip away from ameliorating lupus?
2009, Clinical ImmunologyCitation Excerpt :Alternatively, priming of CD8+ T cells with regulatory properties in the gut can occur via presentation of fed antigens by mucosal DCs in the context of a MHC Ib molecule Qa-1 that is able to recognize self antigens and bacterial heat shock proteins [118,119]. The role of CD8+ T cells have also been examined using genetically engineered CD8 deficient mice [120–122] and in mice treated with anti-CD8 antibodies [109,110,123]. In all the studies, oral tolerance was induced normally suggesting that there is no absolute requirement for CD8+ T cell in the induction or maintenance of systemic tolerance.
Initiating mechanisms of food allergy: Oral tolerance versus allergic sensitization
2007, Biomedicine and PharmacotherapyCitation Excerpt :Distinct functional subsets of CD8+ cells have been described that may contribute to oral tolerance induction [160–162]. However, their functions have not been clearly defined and there is no absolute requirement for CD8+ T cells in the induction or maintenance of oral tolerance [163]. Another T cell subtype in the immunoregulatory network is represented by the NK T cell that shares properties of NK cells and conventional T cells and is associated with CD1d-restricted responses.
Oral tolerance physiologic basis and clinical applications
2005, Mucosal Immunology, Two-Volume Set
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