Regular ArticleFollistatin: A Multifunctional Regulatory Protein☆,☆☆
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Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-κB pathway in CUMS mice
2022, Experimental NeurologyCitation Excerpt :Follistatin-like 1 (FSTL1), a secreted protein rich in cysteine (SPARC), is widely expressed in human and mouse tissues (Chaly et al., 2014). Since the follistain-like domain of FSTL1 was found to bind to activin, an immunologic role for FSTL1 has been investigated (Phillips and de Kretser, 1998). Previous studies have suggested that FSTL1 is important in inflammation and the regulation of immune cell function in the pathogenesis of rheumatoid arthritis and other immune diseases (Chaly et al., 2014; Li et al., 2019).
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2020, Domestic Animal EndocrinologyCitation Excerpt :It is currently unclear whether this correlation is the result of intramuscular fat distribution, thus increasing leptin concentrations with accumulated muscle, or a combined effect with fluctuating follistatin concentrations [42]. Although increased levels of leptin have a promotional effect on puberty onset [42,97–99,101], follistatin is rather known for its inhibition of FSH, and thus downregulation of the hypothalamic-pituitary-gonadal axis [109–111]. A glycoprotein with multiple paracrine functions, follistatin, binds to the hormone activin, inhibiting FSH and minimizing GnRH receptor activation in the pituitary [110,111].
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Address reprint requests to Dr. David J. Phillips, Institute of Reproduction and Development, Monash Medical Center, Clayton Road, Clayton, Victoria 3168, Australia. Fax: +61 3 9550 3584. E-mail:[email protected].
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Burger, H, GFindlay, JRobertson, Dde Kretser, DPetraglia, F