Short CommunicationGPC6, a Novel Member of the Glypican Gene Family, Encodes a Product Structurally Related to GPC4 and Is Colocalized withGPC5on Human Chromosome 13☆
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Cited by (61)
Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease
2019, Matrix BiologyCitation Excerpt :The heparan sulfate chains on glypicans are attached to the core protein close to the cell membrane and, similar to syndecans, the extracellular part of glypicans can be enzymatically shed from the cell surface. All glypicans except GPC5 are expressed in the heart [78–80]. Mutations in the GPC3 and GPC6 genes cause rare growth disorders, i.e. the Simpson-Golabi-Behmel overgrowth syndrome and the generalized omodysplasia (OMOD1) dwarfism syndrome, respectively [81–85].
Polygenic Causes of Congenital Diaphragmatic Hernia Produce Common Lung Pathologies
2016, American Journal of PathologyGlypican-3 is a biomarker and a therapeutic target of hepatocellular carcinoma
2015, Hepatobiliary and Pancreatic Diseases InternationalAn interstitial duplication of chromosome 13q31.3q32.1 further delineates the critical region for postaxial polydactyly type A2
2010, European Journal of Medical GeneticsMutations in the Heparan-Sulfate Proteoglycan Glypican 6 (GPC6) Impair Endochondral Ossification and Cause Recessive Omodysplasia
2009, American Journal of Human GeneticsCitation Excerpt :Adult height ranges between 132 and 144 cm (−7.0 to −5.5 SD).15 We report that omodysplasia maps to chromosome 13 and is caused by homozygosity for null mutations in GPC6 (MIM 604404), which encodes for the latest described human glypican gene.16 We investigated eight patients and two products of conception from five families (Figure 1) and one additional isolated patient (patient 9).
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. AF111178.
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To whom correspondence should be addressed at the Division of Newborn Medicine, Department of Pediatrics, Washington University Medical School, Box 8116, St. Louis, MO 63110. Telephone: (314) 454-4091. Fax: (314) 454-4875. E-mail:[email protected].