Regular ArticlePatients with Systemic Lupus Erythematosus have Reduced Numbers of Circulating Natural Interferon-α- Producing Cells
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Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 IFN in Cutaneous Lupus: An In-Depth Immunoprofile of Subacute and Discoid Lupus
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2021, ImmunityCitation Excerpt :Plasmacytoid dendritic cells (pDCs) reside in blood and lymphoid organs (Jegalian et al., 2009) but during inflammation they enter tissues where they serve as a major source of type I interferons (IFNs) (Cella et al., 1999; Liu, 2005; Siegal et al., 1999). They play a role during viral infections (Colonna et al., 2004; Reizis, 2019) and are implicated in autoimmune diseases like systemic lupus erythematosus (SLE) (Baccala et al., 2013; Blanco et al., 2001; Cederblad et al., 1998; Sisirak et al., 2014). SLE is a life-threatening disease that can affect multiple organs (Maidhof and Hilas, 2012).
The skin
2021, Lahita’s Systemic Lupus ErythematosusThe pathogenesis of systemic lupus erythematosus: Harnessing big data to understand the molecular basis of lupus
2020, Journal of Autoimmunity
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Correspondence to: Lars Rönnblom, Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden. Fax: +46 18 510133. E- mail:[email protected]