Regular ArticleObstructive Jaundice Impairs Reticuloendothelial Function and Promotes Bacterial Translocation in the Rat
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Sepsis and cirrhosis in growing animals: description of a new experimental model and its pathological and immunological reliability
2020, ClinicsCitation Excerpt :In the current work, the BDL+CLP model technique in young rats was feasible and of rapid execution. Regarding mortality, animals subjected to a greater number of procedures, due to the number of interventions and the accumulation of comorbidities, were expected to have a higher mortality rate as seen in previous works (20,21). This seems to correspond with what is observed in clinical practice, wherein individuals with cirrhosis in the surgical context, and concurrent infectious complications tend to present with higher mortality (22).
Infections of the Biliary Tract
2013, Gastrointestinal Endoscopy Clinics of North AmericaCitation Excerpt :Studies indicate that absence of bile salts and IgA in the intestine leads to a change in the bacterial flora that colonizes the small intestine. Under normal circumstances, colonization of the duodenum and jejunum with coliforms is limited,27,28 but this has been shown to change in studies of bile duct–ligated rats, indicating a shift in the small bowel flora with Escherichia coli predominating.29 In addition to the change in the bacterial flora of the duodenum, intestinal bacteria are more likely to translocate in rodents with ligated bile ducts.30
The ultrastructural research of liver in experimental obstructive jaundice and effect of honey
2008, American Journal of SurgeryManagement of Ascending Cholangitis
2007, Gastrointestinal Endoscopy Clinics of North AmericaCitation Excerpt :Clinically significant infection may follow attempted instrumentation of these patients, especially when adequate biliary drainage is not obtained [15,16]. Duodenal cultures of patients who have biliary obstruction have been shown to contain high concentrations of flora commonly found in the colon, compared with patients who have normal biliary function [14]. The biliary tree is normally sterile and has several protective mechanisms to prevent infection [17].