Review ArticleMediators of Asthma: Nitric oxide
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Cited by (69)
Exhaled Nitric Oxide: An Update
2018, Immunology and Allergy Clinics of North AmericaFlavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor
2017, Journal of Biological ChemistryCitation Excerpt :Individual flavones (10 μm each) significantly repressed PMA-induced Muc5AC up-regulation (Fig. 2a), suggesting they may have an anti-inflammatory role in airway cells. We tested another important marker of inflammation, inducible nitric-oxide synthase (iNOS) (74–77). Whereas acute NO production can be antibacterial, chronic excessive NO production through transcriptional up-regulation of iNOS may exacerbate and prolong inflammation.
The soluble guanylyl cyclase activator BAY 60-2770 inhibits murine allergic airways inflammation and human eosinophil chemotaxis
2016, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Nitric oxide (NO) is a mediator involved in many diverse physiopathological signaling processes, and is produced by action of the classic family of NO synthases (NOS), namely the constitutive calcium-, calmodulin-dependent endothelial and neuronal NOS (eNOS and nNOS) and the inducible calcium-independent NOS (iNOS) [3]. The isotype iNOS is highly expressed in eosinophils and lung tissues of asthmatic patients and animals [4,5]. The airway eosinophilia during asthma exacerbation is correlated with high levels of iNOS-derived NO in exhaled air from asthmatic patients, contributing to loss of the lung capacity [5–8].
Exhaled Nitric Oxide
2012, Immunology and Allergy Clinics of North AmericaNitric oxide metabolism in asthma pathophysiology
2011, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Airway epithelium expresses NOS2 in the healthy lung [34,53,54], where the high levels of NO are involved in innate host defense [46]. The NOS2 protein and activity are greatly increased in asthmatic airways [35,55,56] and inhibition of NOS2-derived NO attenuates antigen-induced airway constriction, inflammatory, and remodeling processes, reducing both collagen and elastic fiber deposition in a guinea pig model of allergic asthma [57,58]. NOS2 gene expression is substantially regulated at the level of transcription [45,46,59–62].
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Corresponding author: Dr David A. Groneberg, MD, Division of Allergy Research, Dept. of Pediatric Pneumology and Immunology, Biomedical Research Center, Forum 4, Charité Campus-Virchow, Augustenburger Platz 1, 13353 Berlin, Germany. Tel: +49-30-450559-839; Fax: +49-30-450559-951; E-mail: [email protected]