Abstract
Using locus- and allele-specific oligonucleotide probes, we have studied the polymorphism of the HLA-DR β III locus within the haplotypes of the DRw52 supertypic group. DNA from a number of homozygous typing cells typed for both Dw and DR was used. The DR β III polymorphisms, DRw52a and DRw52b, do not segregate with Dw typing, or with DR typing, indicating that the determinants responsible for Dw-defined T -cell response and for DR haplotypic recognition are not encoded by the DR β III locus. Hence, we can conclude that these DR specificities are encoded by the other functional DR locus, DR β I, while the DR β III locus encodes only the supertypic product.
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Gorski, J., Tilanus, M., Giphart, M. et al. Oligonucleotide genotyping shows that alleles at the HLA-DR β III locus of the DRw52 supertypic group segregate independently of known DR or Dw specificities. Immunogenetics 25, 79–83 (1987). https://doi.org/10.1007/BF00364271
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DOI: https://doi.org/10.1007/BF00364271