Summary
IgA-containing plasma cells in the periductal gland tissue are part of the special secretory immune system of the salivary glands. The reaction of Ig-containing plasma cells (localization, frequency, specific Ig-content) was analyzed by the indirect immunoperoxidase method in chronic recurrent parotitis (9 cases), chronic myoepithelial parotitis (benign lymphoepithelial lesion, Sjögren's syndrome; 8 cases), and malignant lymphoma associated with chronic myoepithelial parotitis (11 cases). The following results were obtained:
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1.
In chronic recurrent parotitis, parallel to the increase in IgA in the salivary secretion, a marked multiplication of IgA-containing plasma cells was found in the inflammatory infiltrate and the remaining non-inflamed periductal parenchyma of the parotid gland. In the marginal zone of inflammation, a slight increase of IgG-containing plasma cells was also observed.
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2.
In chronic myoepithelial parotitis, the total plasma cellular infiltration was slightly less distinct than in chronic recurrent parotitis. The most remarkable increase in Ig-containing plasma cells developed in the marginal zones — away from the myoepithelial cellular islands — as well as in the area of ductular proliferations, and was characterized by a strong increase of IgG-containing plasma cells. At the same time, a slight increase of IgM-containing plasma cells was observed. No plasma cells were found in the myoepithelial cellular islands.
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3.
In the malignant lymphomas associated with myoepithelial parotitis, which were mainly highly differentiated lymphomas (immunocytomas, centrocytic-centroblastic lymphomas) and rarely poorly differentiated immunoblastic lymphomas, there was a distinct decrease of IgG-containing plasma cells when compared with the numbers in this group without lymphoma.
The differing degrees of prevalence and Ig-content of the plasma cells partly describe the change taking place in the local secretory immune system of the parotid gland. The possible relationships between chronic recurrent parotitis and auto-immune myoepithelial parotitis on one hand and the stages of transition (prelymphoma) to malignant lymphoma on the other, are discussed.
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References
Anderson LG, Talal N (1972) The spectrum of benign to malignant lymphoproliferation in Sjögren's syndrome. Clin Exp Immunol 10:199–221
Batsakis JG, Bernacki EG, Rice DH, Strebler ME (1975) Malignancy and the benign lymphoepithelial lesion. Laryngoscope 85:389–399
Becker W, Haubrich J, Seifert G (1978) Krankheiten der Kopfspeicheldrüsen. In: Berendes J (ed) Hals-Nasen-Ohren-Heilkunde in Praxis und Klinik, Bd 3. Georg Thieme, Stuttgart, p 12
Bertram U, Halberg P (1965) Organ antibodies in Sjögren's syndrome. Acta allergol (Kbh) 20:472–483
Bloch KH (1976) Sjögren's syndrome. In: Miescher PA, Mueller-Eberhard MJ (ed) Textbook of Immunopathology, Bd 2, Grune and Stratton, New York San Francisco London, S 1037
Burns J (1975) Background staining and sensitivity of unlabelled antibody-enzyme PAP method. Comparison with peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material. Histochemistry 43:291–297
Brandtzaeg P (1976) Immunoglobulin system of oral mucosa and saliva. In: Dolby AE (ed) Oral mucosa in health and disease. Blackwell scientific publications, Oxford London Edinburg Melbourne, S 137
Donath K, Seifert G (1972) Ultrastruktur und Pathogenese der myoepithelialen Sialadenitis. Virchows Arch [Pathol Anat] 359:315–329
Faguet GB, Webb HH, Agee JF, Ricks WB, Sharbaugh AH (1978) Immunologically diagnosed malignancy in Sjögren's pseudolymphoma. Am J Med 65:424–429
Feltkamp TEW, van Rossum AL (1968) Antibodies to salivary duct cells and other-antibodies in patients with Sjögren's syndrome and other idiopathic autoimmune-diseases. Clin Exp Immunol 3:1–16
Gumberz Chr v (1980) Über das Vorkommen Immunglobulin-produzierender Plasmazellen bei chronischer Parotitis, malignen Lymphomen und Cystadenolymphomen der Parotis. Dissertation Hamburg
Greenspan JS, Daniels TE, Talal N, Sylvester RA (1974) The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg 37:217–229
Haubrich J (1976) Klinik der nichttumorbedingten Erkrankungen der Speicheldrüsen. Arch Otorhinolaryngol 213:1–59
Heckmayr M, Seifert G, Donath K (1976) Lymphome and Immunsialadenitis. Laryngol Rhinol 55:593–607
Hurlimann J (1971) Immunglobulin-syntheses and transport by human salivary glands. Curr Top Pathol 55:69–108
Lennert K (1978) Malignant lymphomas other than Hodgkin's disease. Histology, Cytology, Ultrastructure, Immunology. In: Uehlinger E (ed) Handbuch der speziellen pathologischen Anatomie und Histologie, Bd. I/Teil 3 B. Springer, New York Heidelberg Berlin
Lennert K, Knecht H, Burkert K (1979) Vorstadien maligner Lymphome. Verh Dtsch Ges Pathol 63:170–196
Löning Th, Burkhardt A, Seifert G, Gebbers J-O (1977) Zur Typisierung der Immunglobuline in oralen Leukopiasien und Karzlnomen. Dtsch Z Mund-Kiefer-Gesichts-Chir 1: 168–177
MacSween RNM, Goudie RB, Anderson JR, Amstrong E, Murray MA, Mason DK, Jasani MK, Boyle JA, Buchanan WW, Williamson J (1967) Occurrence of antibody to salivary duct epithelium in Sjögren's disease, rheumatoid arthritis and other arthritides. Ann Rheum Dis 26:402–411
Pinkus GS, Said JW (1977) Specific identification of intracellular immunoglobulin in paraffin sections of multiple myeloma and macroglobulinemia using an immunoperoxidase technique. Am J Pathol 87:47–58
Seifert G (1979) Wangenschwellungen bei Speicheldrüsenentzündungen. Pathologisch-anatomische Differentialdiagnose der Sialadenitis. HNO 27:119–128
Seifert G (1980) Lymphoid lesions of the oral cavity. Path Res Pract 167:179–203
Seifert G, Burkhardt A (1979) Orale Krebsvorstadien. Verh Dtsch Ges Pathol 63:74–96
Seifert G, Donath K (1976) Die Morphologie der Speicheldrüsenerkrankungen. Arch Otorhinolaryngol 213:111–208 und 371–380
Seifert G, Donath K (1977) Zur Pathogenese des Küttner-Tumors der Submandibularis. Analyse von 349 Fällen mit chronischer Sialadenitis der Submandibularis. HNO (Berlin) 25:81–92
Sternberger LA (1979) Immunocytochemistry. John Wiley and Sons, New York Chichester Brisbane Toronto
Talal N, Asofsky R, Lightbody P (1970) Immunoglobulin synthesis by salivary gland lymphoid cells in Sjögren's syndrome. J Clin Invest 49:49–54
Talal N, Bunim JJ (1964) The development of malignant lymphoma in the course of Sjögren's syndrome. Am J Med 36:529–540
Talal N, Sylvester RA, Daniels TE, Greenspan JS, Williams RC (1974) T- and B-lymphocytes in peripheral blood and tissue lesions in Sjögren's syndrome. J Clin Invest 53:180–189
Tannenbaum H, Pinkus GS, Anderson LG, Sehur PH (1975) Immunologic characterization of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with Sjögren's syndrome. Arthritis Rheum 18:306–314
Tarpley TM, Anderson LG, White CL (1974) Minor salivary gland involvement in Sjögren's syndrome. Oral Surg 37:64–71
Taylor CR (1978) Immunoperoxidase techniques. Arch Pathol Lab Med 102:113–121
Taylor CR, Burns J (1974) The demonstration of plasma cells and other immunoglobulin containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. J Clin Pathol 27:14–20
Taylor CR, Mason DY (1974) The immunohistological detection of intracellular immunoglobulin in formalin-paraffin-sections from multiple myeloma and related conditions using immunoperoxidase technique. Clin Exp Immunol 18:417–429
Tourville DR, Adler RH, Bienenstock J, Tomasi TB Jr (1969) The human secretory immunoglobulin system: Immunohistological localisation of gamma A, secretory “piece”, and lactoferrin in normal human tissues. J Exp Med 129:411–429
Zulman J, Jaffe R, Talal N (1978) Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm. N Engl J Med 299:1215–1219
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Prof. Dr. med. Dr. med. h.c. Carl Krauspe dedicated on the occasion of his 85th birthday
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von Gumberz, C., Seifert, G. Immunoglobulin-containing plasma cells in chronic parotitis and malignant lymphomas of the parotid gland. Virchows Arch. A Path. Anat. and Histol. 389, 79–92 (1980). https://doi.org/10.1007/BF00428669
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DOI: https://doi.org/10.1007/BF00428669