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Specific cellular immune responses to pancreatic antigen in chronic pancreatitis and Sjögren's syndrome

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Abstract

The specific cellular immune response to the partially purified pancreatic antigen was studied by the peripheral blood lymphocyte proliferation assay in patients with chronic pancreatitis, Sjögren's syndrome, and primary biliary cirrhosis. A significant positive result (stimulation index >2.0) was observed in 7 of 21 patients with idiopathic chronic pancreatitis (33%;P<0.05), 6 of 7 patients with Sjögren's syndrome-associated chronic pancreatitis (86%;P<0.0005), and 6 of 11 patients with Sjögren's syndrome (55%;P<0.01), compared to normal controls whose stimulation index was 0.94±0.28 (mean ± SD;n=14; range, 0.56–1.60). On the other hand, patients with alcoholic chronic pancreatitis (17%;n=12), stone-related chronic pancreatitis (0%;n=7), primary biliary cirrhosis-associated chronic pancreatitis (33%;n=3), primary biliary cirrhosis (0%;n=4), systemic lupus erythematosus (17%;n=6), and autoimmune thyroiditis (0%;n=6) showed no significant difference from normal controls. Furthermore, in patients with idiopathic chronic pancreatitis who had positive results, a lymphocyte proliferative response to the pancreatic antigen was observed in T cells, especially in the CD4+ T cell subpopulation. These results suggest that the pancreatic antigen plays a role in the pathogenesis of a part of idiopathic chronic pancreatitis and Sjögren's syndrome in association with T cell responses and, also, suggest that autoimmunity may be a possible etiological factor in chronic pancreatitis.

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References

  1. Marks IN, Bank S, Carey LC, Cooperman M: Chronic pancreatitis: Etiology, clinical aspects, and medical management.In Bockus Gastroenterology, Vol 6 (4th ed), JE Berk (ed). Philadelphia, Saunders, 1985, pp 4020–4040

    Google Scholar 

  2. Gullo L, Durbec JP: Epidemiology and etiology of pancreatitis.In Pancreatitis: Concepts and Classification, KE Gyr, MV Singer, H Sarles (eds). Amsterdam, Elsvier Science, 1984, pp 371–376

    Google Scholar 

  3. Dreiling DA, Soto JM: The pancreatic involvement in disseminated “collagen” disorders. Am J Gastroenterol 66:546–553, 1976

    Google Scholar 

  4. Fenster LF, Buchanan WW, Laster L, Bunim JJ: Studies of pancreatic function in Sjögren's syndrome. Ann Intern Med 61:498–508, 1964

    Google Scholar 

  5. Gobelet C, Gerster JC, Pappoport G, Hiroz CA, Maeder E: A controlled study of the exocrine pancreatic function in Sjögren's syndrome and rheumatoid arthritis. Clin Rheumatol 2:139–143, 1983

    Google Scholar 

  6. Coll J, Navarro S, Tomas R, Elena M, Martinez E: Exocrine pancreatic function in Sjögren's syndrome. Arch Intern Med 149:848–852, 1989

    Google Scholar 

  7. Epstein O, Chapman RWG, Lake-Bakaar G, Foo AY, Rosalki SB, Sherlock S: The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis. Gastroenterology 83:1177–1182, 1982

    Google Scholar 

  8. Fausa O, Kolmannskog F, Ritland S: The pancreatic ducts in primary biliary cirrhosis and sclerosing cholangitis. Scand J Gastroenterol 20 (Suppl 107):32–35, 1985

    Google Scholar 

  9. Fonseca V, Epstein O, Katrak A, Junglee D, Mikhailidis DP, McIntyre N, Dandona P: Serum immunoreactive trypsin and pancreatic lipase in primary biliary cirrhosis. J Clin Pathol 39:638–640, 1986

    Google Scholar 

  10. Bank S, Novis BH, Petersen E, Dowdle E, Marks IN: Serum immunoglobulins in calcific pancreatitis. Gut 14:723–725, 1973

    Google Scholar 

  11. Dani R, Antunes LJ, Ribeiro JEF, Nogueira CED, Ribeiro T: Immunological participation in chronic calcifying pancreatitis. Digestion 11:333–337, 1974

    Google Scholar 

  12. Murray MJ, Thal AP: The clinical significance of circulating pancreatic antibodies. Ann Intern Med 53:548–555, 1960

    Google Scholar 

  13. Fonkalsrud EW, Longmire WP: The occurrence of pancreatic antibodies and the experimental production of pancreatitis with pancreatic antiserum. Surgery 50:134–142, 1961

    Google Scholar 

  14. Lankisch PG, Koop H, Seelig R, Seelig HP: Antinuclear and pancreatic acinar cell antibodies in pancreatic diseases. Digestion 21:65–68, 1981

    Google Scholar 

  15. Antal L, Kávai M, Szabó G, Sonkoly I, Pálóczi K, Szegedi G, Sápy P, Várhelyi I: Immunological investigations in acute and chronic human pancreatitis. Digestion 20:100–105, 1980

    Google Scholar 

  16. Bovo P, Mirakian R, Merigo F, Angelini G, Cavallini G, Rizzini P, Bottazzo GF: HLA molecule expression on chronic pancreatitis specimens: Is there a role for autoimmunity? Pancreas 2:350–356, 1987

    Google Scholar 

  17. Bedossa P, Bacci J, Lemaigre G, Martin E: Lymphocyte subsets and HLA-DR expression in normal pancreas and chronic pancreatitis. Pancreas 5:415–420, 1990

    Google Scholar 

  18. Schütt C, Friemel H, Schulze HA, Zubaidi G: Specific lymphocyte sensitization in chronic pancreatitis. Digestion 13:308–311, 1975

    Google Scholar 

  19. Strand V, Talal N: Advances in the diagnosis and concept of Sjögren's syndrome (autoimmune exocrinopathy). Bull Rheum Dis 30:1046–1052, 1980

    Google Scholar 

  20. Ludwig H, Schernthaner G, Scherak O, Kolarz G: Antibodies to pancreatic duct cells in Sjögren's syndrome and rheumatoid arthritis. Gut 18:311–315, 1977

    Google Scholar 

  21. Okazaki K, Morita M, Tamura S, Nishimori I, Yamamoto Y, Yamamoto Y: Interspecies crossreactive antigen of the pancreatic duct cell prepared by monoclonal antibody. Int J Pancreatol 5:359–377, 1989

    Google Scholar 

  22. Nishimori I, Okazaki K, Yamamoto Y, Morita M, Tamura S, Yamamoto Y: Sensitization against pancreatic antigen in Sjögren's syndrome and chronic pancreatitis (preliminary communication). Digestion 51:71–74, 1992

    Google Scholar 

  23. García-Pugés AM, Navarro S, Ros E, Elena M, Ballesta A, Aused R, Vilar-Bonet J: Reversibility of exocrine pancreatic failure in chronic pancreatitis. Gastroenterology 91:17–24, 1986

    Google Scholar 

  24. Fox RI, Howell FV, Bone RC, Michelson P: Primary Sjögren syndrome: Clinical and immunopathologic features. Semin Arth Rheum 14:77–105, 1984

    Google Scholar 

  25. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arth Rheum 25:1271–1277, 1982

    Google Scholar 

  26. Protti MP, Manfredi AA, Straub C, Howard JF, Conti-Tronconi BM: CD4+ T cell response to the human acetylcholine receptor α subunit in myasthenia gravis. J Immunol 144:1276–1281, 1990

    Google Scholar 

  27. Jones BR: Lacrimal and salivary precipitating antibodies in Sjögren's syndrome. Lancet 2:773–776, 1958

    Google Scholar 

  28. Anderson JR, Gray KG, Beck JS, Kinnear WF: Precipitating autoantibodies in Sjögren's disease. Lancet 2:456–460, 1961

    Google Scholar 

  29. Bertram U, Halberg P: A specific antibody against the epithelium of the salivary ducts in sera from patients with Sjögren's syndrome. Acta Allergol 19:458–466, 1964

    Google Scholar 

  30. Søborg M, Bertram U: Cellular hypersensitivity in Sjögren's syndrome. Acta Med Scand 184:319–322, 1968

    Google Scholar 

  31. Feltkamp TEW, Rossum AL: Antibodies to salivary duct cells, and other autoantibodies, in patients with Sjögren's syndrome and other idiopathic autoimmune diseases. Clin Exp Immunol 3:1–16, 1968

    Google Scholar 

  32. Whaley K, Chisholm DM, Goudie RB, Downie WW, Dick WC, Boyle JA, Williamson J: Salivary duct autoantibody in Sjøgren's syndrome: Correlation with focal sialadenitits in the labial mucosa. Clin Exp Immunol 4:273–282, 1969

    Google Scholar 

  33. Anderson LG, Tarpley TM, Talal N, Cummings NA, Wolf RO, Schall GL: Cellular-versus-humoral autoimmune responses to salivary gland in Sjögren's syndrome. Clin Exp Immunol 13:335–342, 1973

    Google Scholar 

  34. Berry H, Bacon PA, Davis JD: Cell-mediated immunity in Sjögren's syndrome. Ann Rheum Dis 31:209–302, 1972

    Google Scholar 

  35. Sundkvist G, Lindahl G, Koskinen P, Bolinder J: Pancreatic autoantibodies and pancreatic function in Sjögren's syndrome. J Intern Med 229:61–66, 1991

    Google Scholar 

  36. Haspel MV, Onodera T, Prabhakar BS, McClintock PR, Essani K, Ray UR, Yagihashi S, Notkins AL: Multiple organ-reactive monoclonal autoantibodies. Nature 304:73–76, 1983

    Google Scholar 

  37. Nishimori I, Yamamoto Y, Okazaki K, Morita M, Yamamoto Y: Identification of specific immune response to exocretory duct antigen in idiopathic chronic pancreatitis and Sjögren syndrome. Gastroenterology 100 (Suppl):A292, 1991

    Google Scholar 

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Authors and Affiliations

  1. First Department of Internal Medicine, Kochi Medical School, 783, Kochi, Japan

    Isao Nishimori, Kazuichi Okazaki, Yasuro Yamamoto, Masanori Morita, Satoru Tamura & Yasutake Yamamoto

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  1. Isao Nishimori
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  2. Kazuichi Okazaki
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  3. Yasuro Yamamoto
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  4. Masanori Morita
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  5. Satoru Tamura
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  6. Yasutake Yamamoto
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Nishimori, I., Okazaki, K., Yamamoto, Y. et al. Specific cellular immune responses to pancreatic antigen in chronic pancreatitis and Sjögren's syndrome. J Clin Immunol 13, 265–271 (1993). https://doi.org/10.1007/BF00919385

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