Abstract
From October 1987 to March 1991, 21 (8%) superficial early cancers were found among 256 early colorectal cancers (Dukes A and B1). Superficial early cancers were defined as early cancers less than 3 mm in height. These tumors were found scattered throughout the large intestine and were often observed as reddish spots, which were easily overlooked without careful observation. Histologically, 19 (90%) of them were well-differentiated adenocarcinomas, and five (24%) of them reached the submucosal layer. Eighteen (86%) of them were not associated with adenoma.
Similar content being viewed by others
References
Morson BC, Dawson IM, Day DW, Jass JR, Price AB, Williams GT: Morson & Dawson's Gastrointestinal Pathology, 3rd ed. Oxford, Blackwell, 1990
Muto T, Bussey HJ, Morson BC: The evolution of cancer of the colon and rectum. Cancer 36:2251–2270, 1975
Kariya A, Beppu Y, Mizuno M, Takaki M, Mayama S, Tazawa H, Ohmori Y, Fujita M, Nishizawa M: A case of early colonic cancer type IIc associated with familial polyposis coli. Stomach Intest 12:1359–1364, 1977 (in Japanese with English abstract)
Kudo S, Hayashi T, Miura K, Takano Y, Saito S, Kashima Y: The clinico-pathological features of flat and depressed type of early colorectal cancer. Stomach Intest 24:317–329, 1989 (in Japanese with English abstract)
Nagasako K, Yashiro K, Ootashiro Y, Igarashi T, Suzuki S, Hasegawa K: A study on the genesis of depressed-type early colon cancer and its colonoscopic findings. Stomach Instest 24:331–340, 1989 (in Japanese with English abstract)
Kuramoto S, Oohara T: Minute cancers arisingde novo in the human large intestine. Cancer 61:829–834, 1988
Kuramoto S, Oohara T: Flat early cancers of the large intestine. Cancer 64:950–955, 1989
Shimoda T, Ikegami M, Fujisaki J, Matsui T, Aizawa S, Ishikawa E: Early colorectal carcinoma with special reference to its developmentde novo. Cancer 64:1138–1146, 1989
Hirata I, Tanaka M, Sugimoto K, Yoshizumi M, Umegaki E, Masaki H, Ohshiba S: Clinicopathological study on flat and depressed minute colorectal carcinomas. Dig Endosc 3:526–535, 1991
Iishi H, Tatsuta M, Tsutsui S, Imanishi K, Otani T, Okuda S, Ishiguro S, Taniguchi H: Early depressed adenocarcinomas of the large intestine. Cancer 69:2406–2410, 1992
Murakami T: Pathomorphological diagnosis.In Gann Monograph on Cancer Research, Vol 11, T Murakami (ed). Tokyo, University of Tokyo Press, 1971, pp 53–55
Holyoke ED, Lokich J, Wright H: Adjuvant therapy for adenocarcinoma of the colon following clinically curative resection.In Proceedings, Gastrointestinal Tumor Study Group, National Cancer Institute. Bethesda, Maryland, 1975
Imanishi K, Tsutsui S, Fukusaki T, Uehara H, Iishi H, Nakaizumi A, Otani T, Okuda S, Kondo H, Ishikawa H, Kiyohara T: A new cleansing method in preparation for colonoscopy—Magcorol P whole gut lavage method. Clin Rep 24:346–356, 1990 (in Japanese)
Ikegami M: A pathological study on colorectal cancer. Fromde novo carcinoma to advanced carcinoma. Acta Pathol Jpn 37:21–37, 1987
Nakamura K, Shibuya S, Nishizawa M, Makino T: Adenoma-carcinoma sequence of colorectal carcinomas analysed by use of objective indices of grade of atypicality, and their growing processes in early phase. Stomach Intest 20:877–888 1985 (in Japanese with English abstract)
Spjut HJ, Frankel NB, Appel MF: The small carcinoma of the large bowel. Am J Surg Pathol 3:39–46, 1979
Crawford BE, Stromeyer FW: Small nonpolypoid carcinomas of the large intestine. Cancer 51:1760–1763, 1983
Adachi M, Muto T, Okinaga K, Morioka Y: Clinicopathologic features of the flat adenoma. Dis Colon Rectum 34:981–986, 1991
Kobayashi S, Nakamura T, Kano T, Matsumura A: Colorectal cancer: Progress in endoscopic diagnosis. Surg Ther 62:283–289, 1990 (in Japanese)
Iwai A, Koyama H, Iwashita E, Matsuda K, Sasaki J, Aono S, Tokunaga T, Fukushima Y, Adachi Y, Ishizaka H, Kobayashi M, Kawaguchi A, Kanazawa M, Nagao S, Tajiri H, Miyahara T, Niwa H: A study of dye oral administration method for colonoscopy (report 1). Gastroenterol Endosc 33:1143–1148, 1991 (in Japanese with English abstract)
Tatsuta M, Okuda S, Tamura H, Taniguchi H: Endoscopic diagnosis of early gastric cancer by the endoscopic Congo red-methylene blue test. Cancer 50:2956–2960, 1982
Iishi H, Tatsuta M, Okuda S, ishiguro S: Diagnosis of colon tumors by the endoscopic Congo red-methylene blue test. Endoscopy (submitted)
Takemoto T, Tada M, Yanai H, Karita M, Okita K: Significance of strip biopsy, with particular reference to endoscopic “mucosectomy.” Dig Endosc 1:4–9, 1989
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Iishi, H., Kitamura, S., Nakaizumi, A. et al. Clinicopathological features and endoscopic diagnosis of superficial early adenocarcinomas of the large intestine. Digest Dis Sci 38, 1333–1337 (1993). https://doi.org/10.1007/BF01296086
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01296086