Abstract
IgA-class anti-gliadin antibodies (AGA) and IgA-, IgG-, IgM-class anti-reticulin antibodies (ARA) were determined in 1461 persons, representing 84% of a population from the village of Karksi-Nuia. AGA were detected by enzyme-linked immunosorbent assay (ELISA) and ARA by indirect immunofluorescence. Fifty-two (3.5%) persons had IgA-class AGA, of whom 48 and an additional three of four persons with diarrhea were biopsied. All biopsies showed normal small intestinal mucosal architecture. All 1461 persons were negative for ARA. Our results demonstrate that AGA are frequently detected in an adult Estonian population and positivity increases with age in persons with normal small intestinal mucosa. Positivity for AGA does not predict silent undetected celiac disease but rather represents a normal response to dietary antigens in the elderly. Inability to detect ARA suggests that celiac disease does not exist in this population. As none of the AGA-positive but ARA-negative biopsied persons had celiac disease, ARA might be a more specific serologic marker for celiac disease than AGA.
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Savilahti E, Perkkio M, Kalimo K, Viander M, Vainio E, Reunala T: IgA antigliadin antibodies: A marker of mucosal damage in childhood celiac disease. Lancet 1:320–322, 1983
Hällström O: Comparison of IgA-class reticulin and endomysium antibodies in coeliac disease and dermatitis herpetiformis. Gut 30:1225–1232, 1989
Chorzelski TP, Sulej J, Tchorzewska H, Jablonska S, Beutner EH, Kumar V: IgA-class endomysium antibodies in dermatitis herpetiformis and coeliac disease. Ann NY Acad Sci 420:325–334, 1983
Juto P, Fredrikzon B, Hernell O: Gliadin-specific serum immunoglobulins A, E, G, and M in childhood: Relation to small intestinal mucosal morphology. J Pediatr Gastroenterol Nutr 4:723–729, 1985
Ascher H, Lanner Å, Kristiansson B: A new laboratory kit for anti-gliadin IgA at diagnosis and follow-up of childhood celiac disease. J Pediatr Gastroenterol Nutr 10:443–450, 1990
Kumar V, Jain N, Lerner A, Beutner EH, Chorzelski TP, Lebenthal E: Comparative studies of different gliadin preparations in detecting antigliadin antibodies. J Pediatr Gastroenterol Nutr 5:730–734, 1986
Hed J, Lieden G, Ottosson E, Ström M, Walan A, Groth O, Sjögren F, Franzen L: IgA anti-gliadin antibodies and jejunal mucosal lesions in healthy blood donors. Lancet 2:215, 1986
Friis SU, Gudman-Hoyer E: Screening for coeliac disease in adults by simultaneous determination of IgA and IgG gliadin antibodies. Scand J Gastroenterol 21:1058–1062, 1986
Volta U, Molinaro N, Fusconi M, Cassani F, Bianchi FB: IgA antiendomysial antibody test. A step forward in celiac disease screening. Dig Dis Sci 36:752–756, 1991
McMillan SA, Haughton DJ, Biggart JD, Edgar JD, Porter KG, McNeil TA: Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy. Br Med J 303:1163–1165, 1991
Mäki M, Holm K, Lipsanen V: Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Lancet 338:1350–1353, 1991
Collin P, Hällström O, Mäki M, Viander M, Keyriläinen O: Atypical coeliac disease found with serological screening. Scand J Gastroenterol 25:245–250, 1990
Schroeder P: Upper gastrointestinal endoscopy at a student health centre. Scand J Prim Health Care 8:191–195, 1990
Auricchio S, Greco L, Troncone R: What is the true prevalence of coeliac disease? Gastroenterol Int 3:140–142, 1990
Acher H, Krantz I, Kristiansson B: Increasing incidence of coeliac disease in Sweden. Arch Dis Child 66:608–611, 1991
Agreus L, Kraaz W, Lavö B, Nygren O, Sväardsudd K, Tibblin G: Begränsat värde av s-gliadin-antikroppar vid screening av coeliaci i befolkningen. Sven Laekaresaellsk Handl Hyg 100:148, 1991 (abstract)
Husby S, Oxelius VA, Teisner B, Jensenius JC, Svehag SE: Humoral immunity to dietary antigens in healthy adults. Int Arch Allergy Appl Immunol 77:416–422, 1985
Scott H, Brandtzaeg P: Gluten IgA antibodies and coeliac disease. Lancet 1:382–383, 1989
Mäki M, Hällström O, Marttinen A: Reaction of human noncollagenous polypeptides with coeliac disease autoantibodies. Lancet 338:724–725, 1991
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Supported by a grant from the Ministry of Health, Estonia. Dr. Oivi Uibo was also supported by a grant from the Emil Aaltonen Foundation.
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Uibo, O., Uibo, R., Kleimola, V. et al. Serum IgA anti-gliadin antibodies in an adult population sample. Digest Dis Sci 38, 2034–2037 (1993). https://doi.org/10.1007/BF01297081
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DOI: https://doi.org/10.1007/BF01297081