Abstract
The ingestion of a meal stimulates water and ion absorption from the small intestine. The administration of nutrient substances directly to the small bowel can cause dumping symptoms, with intraluminal fluid accumulation and relative systemic hypovolemia. This study compared the effect of oral versus direct jejunal meal delivery on jejunal water and ion absorption, with and without premeal intravenous saline infusion. Jejunal absorption studies (N=40) were performed on dogs with 25 cm proximal jejunal Thiry-Vella fistulas and feeding jejunostomies. Luminal perfusion with [14C]PEG was used to calculate fluxes of water and electrolytes. Five groups were randomly studied: (1) intravenous 0.9% saline alone, (2) oral meal alone, (3) intravenous 0.9% saline plus oral meal, (4) jejunal meal alone, and (5) intravenous 0.9% saline plus jejunal meal. Hydration status was assessed hourly by measurement of hematocrit. Water and electrolyte absorption was significantly stimulated by both oral and jejunal meal delivery (P<0.01). Intravenous saline hydration significantly reduced the hematocrit (P<0.05) but did not alter the proabsorptive response to an oral or jejunal meal. In conclusion, a postprandial signal for proximal jejunal water and electrolyte absorption was stimulated equally by orally or jejunally administered nutrients and was not affected by premeal hydration. These data support the hypothesis that the proabsorptive signal that stimulates water and ion absorption is an enteroenteric phenomenon originating from the small intestine, without implicating pathophysiologic events such as hypovolemia or dumping.
Similar content being viewed by others
References
Yeo CJ, Bastidas JA, Schmieg RE Jr, Zinner MJ: Mealstimulated absorption of water and electrolytes in canine jejunal. Am J Physiol 259:G402-G409, 1990
McFadden DW, Jaffe BM, Ferrara A, Zinner MJ: Jejunal absorptive response to a test meal and its modification by cholinergic and calcium channel blockade in the awake dog. Surg Forum 35:174–176, 1984
Sarr MG, Kelly KA, Phillips SF: Canine jejunal absorption and transit during interdigestive and digestive motor states. Am J Physiol 239:G167-G172, 1980
Bastidas JA, Yeo CJ, Schmieg RE Jr, Zinner MJ: Endogenous opiates in the mediation of early meal-induced jejunal absorption of water and electrolytes. Am J Surg 157:27–32, 1989
Sarr MG, Kelly KA, Phillips SF: Feeding augments canine jejunal absorption via a hormonal mechanism. Dig Dis Sci 26:961–965, 1981
Bastidas JA, Yeo CJ, Schmieg RE Jr, Bastidas JA, Orandle MS, Zinner MJ: Influence of gastric distension and meal composition on jejunal absorption. Surg Forum 40:189–190, 1989
Bastidas JA, Orandle MS, Zinner MJ, Yeo CJ: Small-bowel origin of the signal for meal-induced jejunal absorption. Surgery 108:376–383, 1990
Papasova M, Atanassova E: Adaptation to surgical perturbations.In Handbook of Physiology. Section 6: The Gastrointestinal System, Vol I, Part 2. SG Schultz (ed). Baltimore, Waverly, 1989, pp 1199–1224
Bright-Asare P, Binder HJ: Stimulation of colonic secretion of water and electrolytes by hydroxy fatty acids. Gastroenterology 64:81–88, 1973
Miller DL, Schedl HP: Total recovery studies of nonabsorbable indicators in the rat small intestine. Gastroenterology 58:40–46, 1970
Grossman MI: Integration of neural and hormonal control of gastric secretion. Physiologist 6:349–357, 1963
Go VLW, Hofman AF, Summerskill WHJ: Pancreozymin bioassay in man based on pancreatic enzyme secretion: Potency of specific amino acids and other digestive products. J Clin Invest 49:1558–1564, 1970
Yamada T: Gut hormone release induced by food ingestion. Am J Clin Nutr 42:1033–1039, 1985
Moneta GL, Taylor DC, Helton WS, Mulholland MW, Strandness DE Jr: Duplex ultrasound measurement of postprandial intestinal blood flow: Effect of meal composition. Gastroenterology 95:1294–1301, 1988
Guerrant RL, Carpenter CCJ: Diarrheagenic effect of volume expansion: Intestinal fluid secretion without mucosal adenyl cyclase stimulation. Johns Hopkins Med J 136:209–211, 1975
Higgins JT Jr, Blair NP: Intestinal transport of water and electrolytes during extracellular volume expansion in dogs. J Clin Invest 50:2569–2579, 1971
Duffy PA, Granger DN, Taylor AE: Intestinal secretion induced by volume expansion in the dog. Gastroenterology 75:413–418, 1978
Humphreys MH, Earley LE: The mechanism of decreased intestinal sodium and water absorption after acute volume expansion in the rat. J Clin Invest 50:2355–2367, 1971
Binder HJ, Katz LA, Spencer RP, Spiro HM: The effect of inhibitors of renal transport on the small intestine. J Clin Invest 45:1854–1858, 1966
Parsons BJ, Smyth DH, Taylor CB: The action of phlorrhizin on the intestinal transfer of glucose and waterin vitro. J Physiol (London) 144:387–402, 1958
Author information
Authors and Affiliations
Additional information
Supported in part by research grants from the National Institutes of Health: R29-DK41178 (C.J.Y.), and R01-DK39879 (M.J.Z.).
Rights and permissions
About this article
Cite this article
Anthone, G.J., Mavrophilipos, Z.V., Zinner, M.J. et al. Meal-stimulated canine jejunal ionic absorption. Digest Dis Sci 37, 842–848 (1992). https://doi.org/10.1007/BF01300381
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01300381