Abstract
Eating a 1000-kcal mixed meal stimulates an increase in distal colonic motility. Fat is the dietary component which is the major stimulant of colonic spike activity. In this study the colonic spike activity increased similarly after the mixed meal [19.1±2.4 spike potentials (SP)/30 min] and after the fat meal (19.4±5.4 SP/30 min). Fat stimulated a concentration-dependent increase in colonic motility only when in contact with the gastroduodenal mucosa. Intravenous administration of Liposyn (100 kcal/hr) did not stimulate an increase in colonic spike activity (3.3±1.3 SP/30 min) despite greater increase in plasma total fatty acid levels than after the oral ingestion of fat. In contrast both the oral ingestion and the intravenous administration of an amino acid mixture (Aminosyn) inhibited the gastrocolonic response after the 1000-kcal mixed meal. Thus, these studies demonstrate: (1) fat stimulates colonic motility only through direct mucosal contact, and (2) a mixture of amino acid inhibits colonic motility through either mucosal contact or by circulating in the plasma. The exact neurohumoral mechanisms involved in both of these effects is unknown at present.
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Connell AM, Jones FA, Rowlands EN: Motility of the pelvic colon. IV. Abdominal pain associated with colonic hypermotility after meals. Gut 6:105–112, 1965
Holdstock DJ, Misiewicz JJ: Factors controlling colonic motility: colonic pressures and transit after meals in patients with total gastrectomy, pernicious anaemia or duodenal ulcer. Gut 11:100–110, 1970
Wright SA, Snape WJ Jr, Battle WM, Cohen S, London RL: Effect of dietary components on gastrocolonic response. Am J Physiol 238:G228-G232, 1980
Sullivan MA, Cohen S, Snape WJ Jr: Colonic myoelectrical activity in irritable bowel syndrome: Effect of eating and anticholinergics. N Engl J Med 298:878–883, 1978
Battle WM, Snape WJ Jr, Alavi A, Cohen S, Braunstein S: Colonic dysfunction in diabetes mellitus. Gastroenterology 79:1217–1221, 1980
Battle WM, Cohen S, Snape WJ Jr: Inhibition of postprandial colonic motility after the ingestion of an amino acid mixture. Dig Dis Sci 25:647–652, 1980
Sun EA, Snape WJ Jr, Cohen S, Renny A: The role of opiate receptors and cholinergic neurons in the gastrocolonic response. Gastroenterology 82:689–693, 1982
Snape WJ Jr, Carlson GM, Cohen S: Human colonic myoelectric activity in response to prostigmin and the gastrointestinal hormones. Am J Dig Dis 22:881–887, 1977
Snape WJ Jr, Wright SH, Cohen S, Battle WM: The gastrocolonic response: Evidence for a neural mechanism—neural versus hormonal mediation. Gastroenterology 77:1235–1240, 1979
Snape WJ Jr, Matarazzo SA, Cohen S: Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology 75:373–378, 1978
Sharma KN, Nasset ES: Electrical activity in mesenteric nerves after perfusion of the gut lumen. Am J Physiol 202:725–730, 1962
Walsh JH, Lamers CB, Valenzuela JE: Cholecystokinin—octapeptidelike immunoreactivity in human plasma. Gastroenterology 82:438–444, 1982
Dinoso VP, Meshkinpour H, Lorber SH, Suturrez JG, Chey WY: Motor responses of the sigmoid colon and rectum to exogenous cholecystokinin and secretion. Gastroenterology 65:438–444, 1973
Snape WJ Jr: Interaction of the octapeptide of cholecystokinin and gastrin I with bethanechol in the stimulation of feline colonic smooth muscle. Gastroenterology 84:58–62, 1983
Kirwan WV, Smith AN, Mitchell WD, Falconer JD, Eastwood MA: Bile acids and colonic motility in the rabbit and the human. Gut 16:894–902, 1975
Shiff SJ, Soloway RD, Snape WJ Jr: Mechanism of deoxycholic acid stimulation of the rabbit colon. J Clin Invest 69:985–992, 1982
Morley JE, Levine AS, Yamada T, Gebhard RL, Prigge WF, Shafer RB, Goetz FC, Silvis SE: Effect of exorphins on gastrointestinal function, hormonal release, and appetite. Gastroenterology 84:1517–1523, 1983
Morley JE: Food peptides: A new class of hormones. JAMA 247:2379–2380, 1982
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Levinson, S., Bhasker, M., Gibson, T.R. et al. Comparison of intraluminal and intravenous mediators of colonic response to eating. Digest Dis Sci 30, 33–39 (1985). https://doi.org/10.1007/BF01318368
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DOI: https://doi.org/10.1007/BF01318368