Abstract
This randomised double-blind study examined the frequency of diarrhoea in intensive care unit patients given a fibre-containing feed, Enrich, and a fibre-free feed, Ensure. A daily ‘diarrhoea score’ was calculated from the frequency, volume and consistency of the stools. A score greater than 12 indicated diarrhoea, and greater than 50 severe diarrhoea. Ninety one patients met the criteria for participation: Enrich 45, Ensure 46. The groups were similar in age, sex ratio, feed volume, antibiotic usage, upper gastro-intestinal bleeding prophylaxis and plasma albumin concentrations. Diarrhoea occurred in 16 patients given Enrich and 13 given Ensure, severe diarrhoea affecting 5 and 9 respectively (NS). Forty seven of 343 (14%) Enrich feeding days and 51 of 342 (15%) Ensure feeding days were complicated by diarrhoea — severe diarrhoea: 8 and 12 feeding days (NS). We conclude soy polysaccharide (21 g/L) did not reduce diarrhoea in intensive care unit patients given enteral feeds.
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Cataldi-Becher EL, Seltzer MH, Slocum BA, Jones KW (1983) Complications occurring during enteral nutrition support: a prospective study. JPEN 7:546–552
Kelly TW, Patrick MR, Hillman KM (1983) Study of diarrhea in critically ill patients. Crit Care Med 11:7–9
Dobb GJ (1986) Diarrhoea in the critically ill. Intensive Care Med 12:113–115
Frank HA, Green LC (1979) Successful use of a bulk laxative to control the diarrhoea of tube feeding. Scand J Plast Reconstr Surg 13:193–194
Hart GK, Dobb GJ (1988) The effect of a fecal bulking agent on diarrhea during enteral feeding in the critically ill. JPEN 12:465–468
SAS Institute Inc (1985) SAS/STAT Guide for personal computers, version 6 edition. Cary NC:SAS Institute Inc
Machin D, Campbell MJ (1987) Statistical tables for the design of clinical trials. Blackwell, Oxford London Edinburgh Boston Palo Alto Melbourne
Jones BJM, Lees R, Andrews J, Frost P, Silk DBA (1983) Comparison of an elemental and polymeric enteral diet in patients with normal gastrointestinal function. Gut 24:78–84
Brinson RR, Kolts BE (1987) Hypoalbuminemia as an indicator of diarrheal incidence in critically ill patients. Crit Care Med 15:506–509
Detsky AS, Sackett DL (1985) When was a ‘negative’ clinical trial big enough? Arch Intern Med 145:709–712
Towler SC, Dobb GJ (1988) Hypoalbuminaemia as an indicator of diarrheal incidence in critically ill patients. Crit Care Med 16:817
Peaston MJ (1966) External metabolic studies during nasogastric feeding in serious illnesses requiring intensive care. Br Med J 2:1367–1368
Hillman LC, Peters SG, Fisher CA, Pomare EW (1986) Effects of the fibre components pectin, cellulose and lignin on bile salt metabolism and biliary lipid composition in man. Gut 27:29–36
Binder HJ (1980) Pathophysiology of bile acid- and fatty acid-induced diarrhea. In: Field M, Fordtran JS, Schultz SG (eds) Secretory diarrhea. American Physiological Society, Bethesda MD, pp 154–178
Roedgier WEW (1988) Bacterial short-chain fatty acids and mucosal diseases of the colon. Br J Surg 75:346–348
Rupin H, Simon BM, Soergel KH, Wood EM, Schmitt MG (1980) Absorption of short-chain fatty acids by the colon. Gastroenterology 78:1500–1507
Heymsfield SB, Roongspisuthipong C, Evert M, Casper K, Heller P, Akrabawi SS (1988) Fiber supplementation of enteral formulas: effects on the bioavailability of major nutrients and gastrointestinal tolerence. JPEN 12:265–273
Silk DBA (1989) Fibre and enteral nutrition. Gut 30:246–264
Monypenny FE (1989) Does fibre help reduce the incidence of diarrhoea in the enterally fed neurosurgical intensive care patient? Anaesth Intensive Care 17:223A
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Dobb, G.J., Towler, S.C. Diarrhoea during enteral feeding in the critically ill: A comparison of feeds with and without fibre. Intensive Care Med 16, 252–255 (1990). https://doi.org/10.1007/BF01705161
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DOI: https://doi.org/10.1007/BF01705161