Skip to main content
Log in

When should treatment of acute experimental pancreatitis be started?

The Early Phase of Bile-Induced Acute Pancreatitis

  • Original Papers
  • Published:
Research in Experimental Medicine

Summary

Sodium taurocholate pancreatitis in the rat is a frequently used experimental model for evaluating therapeutical regimes in this disease. It is, however, uncertain when treatment should be started, as the early phase of this experimental model and thus the time when the pancreatitis really develops is unknown. Serum and pancreatic enzymes, as well as pancreatic morphology, were therefore studied 5, 30, and 60min after induction of sodium taurocholate pancreatitis. It was found that increase in serum enzymes and decrease in pancreatic enzymes and morphological changes characteristic for acute pancreatitis develop as early as 5 and 30 min after induction of pancreatitis. Thus, therapy in this model may be started shortly after induction of acute pancreatitis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adler G, Hupp T, Kern HF (1979) Course and spontaneous regression of acute pancreatitis in the rat. Virchows Arch [Pathol Anat] 382:31–47

    Google Scholar 

  2. Aho HJ, Nevalainen TJ (1980) Experimental pancreatitis in the rat. Ultrastructure of sodium taurocholate-induced pancreatic lesions. Scand J Gastroenterol 15:417–424

    PubMed  Google Scholar 

  3. Aho HJ, Nevalainen TJ, Aho AJ (1983) Experimental pancreatitis in the rat. Development of pancreatic necrosis, ischemia, and edema after intraductal sodium taurocholate injection. Eur Surg Res 15:28–36

    PubMed  Google Scholar 

  4. Blamey SL, Imrie CW, O'Neill J, Gilmour WH, Carter DC (1984) Prognostic factors in acute pancreatitis. Gut 25:1340–1346

    PubMed  Google Scholar 

  5. Bockman DE, Schiller WR, Suriyapa C, Mutchler JHW, Anderson MC (1973) Fine structure of early experimental acute pancreatitis in dogs. Lab Invest 28:584–592

    PubMed  Google Scholar 

  6. Brackett KA, Crocket A, Joffe SN (1983) Ultrastructure of early development of acute pancreatitis in the rat. Dig Dis Sci 28:74–84

    PubMed  Google Scholar 

  7. Buschmann-Kaspari H (1986) Diagnostische Wertigkeit von Pankreasenzymentgleisungen bei akuter Pankreatitis — einschließlich Methodenvergleich — und Korrelation der Enzymverläufe mit dem klinischen Krankheitsverlauf. Dissertation, Med Fak Univ Göttingen

  8. Dickson AP, Foulis AK, Imrie CW (1986) Histology and bacteriology of closed duodenal loop models of experimental acute pancreatitis in the rat. Digestion 34:15–21

    PubMed  Google Scholar 

  9. Erlanger BF, Kokowsky N, Cohen W (1961) The preparation and properties of two new chromogenic substrates of trypsin. Arch Biochem Biophys 95:271–278

    PubMed  Google Scholar 

  10. Ferrie MM, O'Hare R, Joffe SN (1978) Acute and chronic pancreatitis in the rat caused by a closed duodenal loop. Digestion 18:280–285

    PubMed  Google Scholar 

  11. Freeny PC, Lawson TL (1982) Radiology of the pancreas. Springer, Berlin Heidelberg New York

    Google Scholar 

  12. Gamklou R, Edlund Y (1966) Ductal factors in the pathogenesis of acute pancreatitis in the rat. Scand J Gastroenterol 1:94–100

    PubMed  Google Scholar 

  13. Heinkel K (1953) Die Ratte als Versuchstier in der experimentellen Pankreasdiagnostik. II. Mitteilung. Die Erzeugung einer akuten hämorrhagischen Pankreatitis durch Injektion von Gallensäure in den Ductus pancreaticus. Klin Wochenschr 31:815

    PubMed  Google Scholar 

  14. Horn J, Heymer B, Merkle N, Meyer H, Diebolder H (1980) Die duktale Obstruktion als pathogenetischer Faktor der akuten Pankreatitis. Eine tierexperimentelle Untersuchung. Z Gastroenterol 18:98–106

    PubMed  Google Scholar 

  15. Lankisch PG (1984) Acute and chronic pancreatitis. An update on management. Drugs 28:554–564

    PubMed  Google Scholar 

  16. Lankisch PG, Ihse I (1987) Bile-induced acute experimental pancreatitis. Scand J Gastroenterol 22:257–260

    PubMed  Google Scholar 

  17. Lankisch PG, Winckler K, Bokermann M, Schmidt H, Creutzfeldt W (1974) The influence of glucagon on acute experimental pancreatitis in the rat. Scand J Gastroenterol 9:725–729

    PubMed  Google Scholar 

  18. Lankisch PG, Koop H, Winckler K, Kunze H, Vogt W (1978) Indomethacin treatment of acute experimental pancreatitis in the rat. Scand J Gastroenterol 13:629–633

    Google Scholar 

  19. Lankisch PG, Koop H, Winckler K, Schmidt H (1979) Continuous peritoneal dialysis as treatment of acute experimental pancreatitis in the rat. I. Effect on length and rate of survival. Dig Dis Sci 24:111–116

    PubMed  Google Scholar 

  20. Lankisch PG, Pohl U, Otto J, Göke B (1985) Therapeutic effects of camostate (FOY 305) in acute experimental pancreatitis. Dig Dis Sci 30:979

    Google Scholar 

  21. Lombardi B, Estes LW, Longnecker DS (1975) Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. Am J Pathol 79:465–480

    PubMed  Google Scholar 

  22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the foline phenol reagent. J Biol Chem 193:265–275

    PubMed  Google Scholar 

  23. Maclean N (1977) The role of the surviving pancreas in late fatalities of acute pancreatitis. Br J Surg 64:345–346

    PubMed  Google Scholar 

  24. Murphy D, Imrie CW, Pack A, Davidson JF, Blumgart LH (1976) The mechanism of acute respiratory insufficiency in acute pancreatitis. Br J Surg 63:669

    Google Scholar 

  25. Nevalainen TJ, Seppä A (1975) Acute pancreatitis caused by closed duodenal loop in the rat. Scand J Gastroenterol 10:521–527

    PubMed  Google Scholar 

  26. Pfeffer RB, Stasior O, Hinton JW (1957) The clinical picture of the sequential development of acute hemorrhagic pancreatitis in the dog. Surg Forum 8:248–251

    PubMed  Google Scholar 

  27. Popper HL, Necheles H, Russell KC (1948) Transition of pancreatic edema into pancreatic necrosis. Surg Gynecol Obstet 87:79–82

    Google Scholar 

  28. Ranson JHC, Rifkind KM, Roses DF, Fink SD, Eng K, Localio SA (1974) Objective early identification of severe acute pancreatitis. Am J Gastroenterol 61:443–451

    PubMed  Google Scholar 

  29. Rao SS, Watt IA, Donaldson LA, Crocket A, Joffe SN (1981) A serial histologic study of the development and progression of acute pancreatitis in the rat. Am J Pathol 103:39–46

    PubMed  Google Scholar 

  30. Rick W (1969) Kinetischer Test zur Bestimmung der Serumlipaseaktivität. Z Klin Chem Klin Biochem 7:530–539

    Google Scholar 

  31. Rick W, Stegbauer HP (1970) α-Amylase. Messung der reduzierenden Gruppen. In: Bergmeyer HU (Hrsg) Methoden der enzymatischen Analyse, Bd 1, 2. Aufl. Verlag Chemie, Weinheim/Bergstraße

    Google Scholar 

  32. Seelig R, Lankisch PG, Koop H, Winckler K, Kaboth U, Seelig HP (1978) Complement system in sodium taurocholate pancreatitis in the rat. Res Exp Med 174:57–65

    Google Scholar 

  33. Wanke M (1970) Experimental acute pancreatitis. Curr Top Pathol 52:64–142

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lankisch, P.G., Pohl, U., Otto, J. et al. When should treatment of acute experimental pancreatitis be started?. Res. Exp. Med. 188, 123–129 (1988). https://doi.org/10.1007/BF01852268

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01852268

Key words

Navigation