Abstract
We studied eight patients who had orthotopic liver transplantation for fulminant hepatic failure in the course of acute non-A, non-B hepatitis. HBV DNA was searched for extensively in the liver tissue by PCR using several sets of primers in conventional and heminested reactions. All patients were negative for HBV DNA in liver tissue by all assays employed; furthermore, they were negative for HEV RNA, HCV RNA, and HBV DNA in serum. Although the causative role of HEV and HCV in fulminant non-A, non-B hepatitis cannot be excluded, our data do not support a causative association between this syndrome and HBV infection.
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Trey C, Davidson CJ: The management of fulminant hepatic failure.In Progress in Liver Diseases, Vol. 3. H Popper, F Schaffner (eds). New York, Grune and Stratton, 1970, pp 282–298
Bernuau J, Rueff B, Benhamou J-P: Fulminant and subfulminant liver failure: Definitions and causes. Sem Liver Dis 6:97–106, 1986
Wright TL, Mamish D, Combs C, Kim M, Donegan E, Ferrell L, Lake J, Roberts J, Ascher NL: Hepatitis B virus and apparent fulminant non-A, non-B hepatitis. Lancet 339:952–955, 1992
Goldsmith R, Yarbough PO, Reyes GR, Fry KE, Gabor KA, Kamel M, Zakaria S, Amer S, Ghaffar Y: Acute sporadic hepatitis E infections in Egyptian children diagnosed by IgM and IgG serologic tests. Lancet 339:328–331, 1992
Tsarev SA, Emerson SU, Reyes GR, Tsareva TS, Legters LJ, Malik IA, Iqbal M, Purcell RH: Characterization of a prototype strain of hepatitis E virus. Proc Natl Acad Sci USA 89:559–563, 1992
Yanagi M, Kaneko S, Unoura M, Murakammi S, Kobayashi K, Sugihara J, Ohnishi H, Muto Y: Hepatitis C virus in fulminant hepatic failure. N Engl J Med 324:1895, 1991 (correspondence)
Feray C, Gigou M, Samuel D, Reyes G, Bernuau J, Reynes M, Bismuth H, Bréchot C: Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitis. Gastroenterology 104:549–555, 1993
Liang J, Jeffers L, Reddy RK, Silva MO, Cheinquer H, Findor A, De Medina M, Yarbough PO, Reyes GR, Schiff R: Fulminant or subfulminant non-A, non-B viral hepatitis: The role of hepatitis C and E viruses. Gastroenterology 104:556–562, 1993
Sallie R, Tibbs C, Silva AE, Sheron N, Eddleston A, Williams R: Detection of hepatitis “E” but not “C” in sera of patients with fulminant hepatitis. Hepatology 14:68A, 1991 (abstract)
Laskus T, Persing DH, Nowicki MJ, Mosley JW, Rakela J: Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States. Gastroenterology 105:1173–1178, 1993
Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M: Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 324:1699–1704, 1991
Lee CH, Cheng C, Wang J, Lumeng L: Identification of hepatitis C viruses with a nonconserved sequence of the 5′ untranslated region. Hepatology 14:129, 1991 (abstract)
Yokosuka O, Tagawa M, Omata M: PCR detection of hepatitis B virus DNA.In Diagnostic Molecular Biology. Principles and Applications. DH Persing, TF Smith, FC Tenover, TJ White (eds). Washington, DC, American Society for Microbiology, 1993, pp 322–326
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This study was supported by Grant CR20 from the Mayo Clinic and Foundation. D.H.P. is supported by Public Health Service grants AI 32403, AR 41497, and AI 30548 from the National Institutes of Health.
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Laskus, T., Rakela, J., Wiesner, R.H. et al. Lack of evidence for hepatitis B virus (HBV) infection in fulminant non-A, non-B hepatitis. Digest Dis Sci 39, 1677–1682 (1994). https://doi.org/10.1007/BF02087775
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DOI: https://doi.org/10.1007/BF02087775