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Influence ofHelicobacter pylori on gastric mucosal adaptation to naproxen in man

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

Our objective was to determine whetherH. pylori influences gastric mucosal injury and adaptation caused by naproxen. Twenty-four healthy volunteers, 12H. pylori-positive and 12H. pylori-negative, were given a 28-day course of naproxen 500 mg twice a day. They were each gastroscoped to assess gastric mucosal damage and mucosal blood flow before and at 1, 7, and 28 days during treatment. Maximal gastric mucosal damage (median grade+IQR) occurred during the first 24 hr in both groups and was of similar magnitude (H. pylori-positive: 2.5, 2.0–3.0P<0.01;H. pylori-negative: 2.0, 1.0–3.0P<0.01). This damage was associated with a fall in antral but not corpus mucosal blood flow. With continued NSAID administration, gastric damage resolved confirming adaptation (H. pylori-positive 1.0, 0–2.0,H. pylori-negative: 1.0, 0–1.0) and antral mucosal blood flow returned to baseline in both groups by day 28. These observations suggest that initial gastric mucosal injury is not influenced byH. pylori colonization and adaptation occurs regardless of its presence.

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Authors and Affiliations

  1. Department of Gastroenterology Manchester Royal Infirmary, Bury General Hospital, Greater Manchester, UK

    G. R. Lipscomb MBBS, N. Wallis MBBS, G. Armstrong MD, M. J. Goodman DPhil &  W. D. W. Rees MD

  2. Department of Medicine, Bury General Hospital, Greater Manchester, UK

    G. R. Lipscomb MBBS, N. Wallis MBBS, G. Armstrong MD, M. J. Goodman DPhil &  W. D. W. Rees MD

  3. Department of Gastroenterology, Hope Hospital, Salford Royal Hospitals NHS Trust, Stott Lane, M6 8HD, Salford, UK

    G. R. Lipscomb MBBS, N. Wallis MBBS, G. Armstrong MD, M. J. Goodman DPhil &  W. D. W. Rees MD

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  1. G. R. Lipscomb MBBS
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  2. N. Wallis MBBS
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  3. G. Armstrong MD
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  4. M. J. Goodman DPhil
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  5. W. D. W. Rees MD
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Lipscomb, G.R., Wallis, N., Armstrong, G. et al. Influence ofHelicobacter pylori on gastric mucosal adaptation to naproxen in man. Digest Dis Sci 41, 1583–1588 (1996). https://doi.org/10.1007/BF02087904

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  • DOI: https://doi.org/10.1007/BF02087904

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